SML2386

Cycloguanil hydrochloride

≥95% (HPLC)

• Synonym(s): 1-(4-chlorophenyl)-1,6-dihydro-6,6-dimethyl-1,3,5-triazine-2,4-diamine hydrochloride
• Empirical Formula (Hill Notation): C₁₁H₁₄ClN₅ · HCl
• CAS Number: 152-53-4
• Molecular Weight: 288.18
• UNSPSC Code: 12352200
• MDL number: MFCD00035308
• NACRES: NA.21
• Assay: ≥95% (HPLC)
• Form: powder
• Storage condition: desiccated

Properties

• assay: ≥95% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: H₂O: 2 mg/mL, clear
• storage temp.: −20°C
• SMILES string: Clc1ccc(cc1)N2C(NC(=N)NC2=N)(C)C.Cl
• InChI: 1S/C11H14ClN5.ClH/c1-11(2)16-9(13)15-10(14)17(11)8-5-3-7(12)4-6-8;/h3-6H,1-2H3,(H4,13,14,15,16);1H
• InChI key: MOUAPRKJJUXEIE-UHFFFAOYSA-N

Description

Application

Cycloguanil hydrochloride is suitable for use as a positive control in screening Plasmodium falciparum strains in microdilution radioisotope antiplasmodial bioassay. It may also be used as internal standard in high performance liquid chromatography for the quantification of urine and plasma samples.

Biochem/physiol Actions

Cycloguanil, a metabolite of proguanil, is a potent dihydrofolate reductase inhibitor.

Dihydrofolate reductase inhibitor, metabolite of proguanil

Cycloguanil is it a potential antimalarial drug. It is hydrophilic in nature. Cycloguanil acts as a substrate for the enzyme organic cation transporter 1 (OCT1).

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Codes: H319
• Precautionary Statements: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Eye Irrit. 2
• Storage Class: 4.1B - Flammable solid hazardous materials
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable