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SML2244

AC1903

≥98% (HPLC)

Synonym(s):

N-(2-Furanylmethyl)-1-(phenylmethyl)-1H-benzimidazol-2-amine

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Size/SKUAvailabilityPrice
5 mg
Please contact Customer Service for Availability
2 260,00 CZK
1 921,00 CZK

About This Item

Empirical Formula (Hill Notation):
C19H17N3O
CAS Number:
831234-13-0
Molecular Weight:
303.36
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD06609959
Assay:
≥98% (HPLC)
Form:
powder

1 921,00 CZK

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assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

C12=CC=CC=C1N=C(NCC3=CC=CO3)N2CC4=CC=CC=C4

InChI

1S/C19H17N3O/c1-2-7-15(8-3-1)14-22-18-11-5-4-10-17(18)21-19(22)20-13-16-9-6-12-23-16/h1-12H,13-14H2,(H,20,21)

InChI key

OECUWHDVQIITIS-UHFFFAOYSA-N

Application

AC1903 has been used as a drug candidate in a high-throughput agar colony formation assay to identify its therapeutic efficiency against medulloblastoma.

Biochem/physiol Actions

AC1903 is a specific inhibitor of TRPC5, the transient receptor potential canonical channel 5, a Ca2+ permeable nonselective cation channel highly expressed in brain and kidney. AC1903 did not inhibit TRPC4 or TRPC6 currents and showed no off-target effects in kinase profiling assays. It specifically blocked TRPC5 channel activity in glomeruli of proteinuric rats, suppressed severe proteinuria, showing a therapeutic benefit in a rat model of hypertensive proteinuric kidney disease.
Specific inhibitor of TRPC5
Chronic administration of AC1903 averts the loss of podocytes in a transgenic rat model of focal segmental glomerulosclerosis (FSGS).

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

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Questions

  1. Is this compound reconstituted with bactrostatic water like a peptide? 

    1 answer

    1. This product is supplied as a powder and should be prepared as a stock solution by dissolving in DMSO at 2 mg/mL. The DMSO stock can then be diluted into the desired aqueous buffer or culture medium as needed. Higher stock concentrations may be limited by solubility and can vary by lot. This material is not sterile and should be sterile-filtered prior to use in cell culture. Please see the link below to access a Certificate of lot interest: https://www.sigmaaldrich.com/product/sigma/sml2244#product-documentation

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