SML1975

UCB35625

>97% (HPLC)

• Synonym(s): trans-1-(1-Cycloocten-1-ylmethyl)-4-[[(2,7-dichloro-9H-xanthen-9-yl)carbonyl]amino]-1-ethyl-piperidinium iodide
• Empirical Formula (Hill Notation): C₃₀H₃₇Cl₂IN₂O₂
• CAS Number: 202796-42-7
• Molecular Weight: 655.44
• NACRES: NA.77
• UNSPSC Code: 12352200
• MDL number: MFCD09971133
• Assay: >97% (HPLC)
• Form: powder

Properties

• assay: >97% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• InChI: 1S/C30H36Cl2N2O2.HI/c1-2-34(20-21-8-6-4-3-5-7-9-21)16-14-24(15-17-34)33-30(35)29-25-18-22(31)10-12-27(25)36-28-13-11-23(32)19-26(28)29;/h8,10-13,18-19,24,29H,2-7,9,14-17,20H2,1H3;1H/b21-8+;/t24-,34-;
• InChI key: FOAFBMYSXIGAOX-MUMZCOSOSA-N

Description

Biochem/physiol Actions

High affinity antagonist for CCR1 and CCR3 receptors, partial agonist at CCR2 and CCR5 receptors

UCB35625 is a high affinity antagonist for CCR1 and CCR3 receptors. Also both UCB35625 and its enantiomer J113863 exhibit low binding affinity toward CCR2 and CCR5 where they activate three G_i and two G₀ protein isoforms. UCB35625 does not activate G12 protein isoform. J113863 binding to CCR2 and CCR5 induce the recruitment of b-arrestin 2 whereas UCB35625 did not. J113863 and UCB35625 are biased ligands for the chemokine receptors CCR2 and CCR5.

Safety Information

• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable