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SML1938

LY450139

≥98% (HPLC)

Synonym(s):

(2S)-2-Hydroxy-3-methyl-N-[(1S)-1-methyl-2-oxo-2-[[(1S)-2,3,4,5-tetrahydro-3-methyl-2-oxo-1H-3-benzazepin-1-yl]amino]ethyl]-butanamide, LY 450139, LY-450139, Semagacestat

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Size/SKUAvailabilityPrice
5 mg
Please contact Customer Service for Availability
2 950,00 CZK
2 507,50 CZK
25 mg
Please contact Customer Service for Availability
11 900,00 CZK

About This Item

Empirical Formula (Hill Notation):
C19H27N3O4
CAS Number:
Molecular Weight:
361.44
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder

2 507,50 CZK

List Price2 950,00 CZKSave 15%
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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C([C@@H](NC([C@@H](O)C(C)C)=O)C)N[C@@H](C1=CC=CC=C1CCN2C)C2=O

InChI

1S/C19H27N3O4/c1-11(2)16(23)18(25)20-12(3)17(24)21-15-14-8-6-5-7-13(14)9-10-22(4)19(15)26/h5-8,11-12,15-16,23H,9-10H2,1-4H3,(H,20,25)(H,21,24)/t12-,15-,16-/m0/s1

InChI key

PKXWXXPNHIWQHW-RCBQFDQVSA-N

Biochem/physiol Actions

LY450139 (Semagacestat) is a notch-sparing, potent and selective gamma-secretase inhibitor. LY450139 lowers plasma and cerebrospinal fluid Aβ in humans.
Notch-sparing, potent and selective gamma-secretase inhibitor and inverse modulator of Aβ

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This Item
SML0943S1697M5449
description

≥98% (HPLC)

description

-

description

≥98% (HPLC), solid

description

≥98% (HPLC), powder

form

powder

form

powder

form

solid

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 20 mg/mL, clear

solubility

H2O: 2 mg/mL, clear (warmed)

solubility

H2O: >5 mg/mL

solubility

H2O: 10 mg/mL, clear

color

white to beige

color

orange to dark red

color

white

color

orange to red


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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