SML1880
SPL-334
≥98% (HPLC)
Synonym(s):
4-{[2-[(2-Cyanobenzyl)thio]-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl]methyl}benzoic acid
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| Size/SKU | Availability | Price |
|---|---|---|
25 mg | Please contact Customer Service for Availability | CZK 9,000.00 |
About This Item
Empirical Formula (Hill Notation):
C22H15N3O3S2
CAS Number:
Molecular Weight:
433.50
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 20 mg/mL, clear
storage temp.
2-8°C
SMILES string
OC(C1=CC=C(CN2C(SCC3=CC=CC=C3C#N)=NC(C=CS4)=C4C2=O)C=C1)=O
InChI key
UWWSCLNCHCROLL-UHFFFAOYSA-N
Biochem/physiol Actions
SPL-334 is an inhibitor of S-Nitrosoglutathione reductase (GSNOR), the enzyme responsible for regulating cellular concentrations of S-Nitrosoglutathione (GSNO), which plays a critical role in nitric oxide signaling in the respiratory tract. In a mouse model of allergic airway inflammation, SPL-334 reduced airway hyperreactivity, and in a bleomycin injury model of interstitial lung disease, SPL-334 reduced lung inflammation and fibrosis. Studies for treatment of asthma, idiopathic pulmonary fibrosis (IPF), and inflammation are ongoing.
SPL-334 is an inhibitor of S-Nitrosoglutathione reductase (GSNOR).
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This Item | |||
|---|---|---|---|
| form powder | form powder | form powder | form powder |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥97% (HPLC) | assay ≥95% (HPLC) |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. −20°C |
| solubility DMSO: 20 mg/mL, clear | solubility DMSO: 2 mg/L, clear | solubility DMSO: 10 mg/mL, clear | solubility DMSO: 0.5 mg/mL, clear (warmed) |
| color white to beige | color white to beige | color white to beige | color white to light brown |
hcodes
pcodes
Hazard Classifications
Aquatic Chronic 4
Storage Class
11 - Combustible Solids
wgk
WGK 3
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