SML1657
Gefitinib
≥98% (HPLC), powder, EGFR TK inhibitor
Synonym(s):
N-(3-Chloro-4-fluoro-phenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine, ZD1839
Select a Size
| Size/SKU | Availability | Price |
|---|---|---|
10 mg | Please contact Customer Service for Availability | 2 710,00 CZK |
50 mg | Please contact Customer Service for Availability | 10 900,00 CZK 9 265,00 CZK |
About This Item
Product Name
Gefitinib, ≥98% (HPLC)
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 10 mg/mL, clear
storage temp.
room temp
SMILES string
COC(C=C(N=CN=C1NC2=CC(Cl)=C(F)C=C2)C1=C3)=C3OCCCN4CCOCC4
InChI
1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27)
InChI key
XGALLCVXEZPNRQ-UHFFFAOYSA-N
Gene Information
human ... EGFR(1956)
Application
- To study its effective use in endometrial cancer therapy
- Cell proliferation, cell cycle and apoptosis assays
- Cell viability assay and colony formation assay
Biochem/physiol Actions
Gefitinib has a higher affinity for ATP (adenosine triphosphate) binding site in the EGFR tyrosine kinase domain than ATP. Hence, gefitinib is known to inhibit the progression of endometrial cancer.
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This Item | |||
|---|---|---|---|
| description ≥98% (HPLC) | description European Pharmacopoeia (EP) Reference Standard | description European Pharmacopoeia (EP) Reference Standard | description United States Pharmacopeia (USP) Reference Standard |
| assay ≥98% (HPLC) | assay - | assay - | assay - |
| form powder | form - | form - | form - |
| Quality Level 100 | Quality Level - | Quality Level - | Quality Level - |
| storage temp. room temp | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility DMSO: 10 mg/mL, clear | solubility - | solubility - | solubility - |
| color white to beige | color - | color - | color - |
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Signal Word
Danger
Hazard Codes
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Chronic 1 - Carc. 2 - Eye Dam. 1 - Repr. 1B - Skin Irrit. 2 - STOT RE 2 Oral
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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