SML1554
S3QEL 2
superoxide production inhibitor, powder
Synonym(s):
1-(3,4-Dimethylphenyl)-N,N-dipropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
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| Size/SKU | Availability | Price |
|---|---|---|
10 mg | Please contact Customer Service for Availability | 2 340,00 CZK |
50 mg | Please contact Customer Service for Availability | 9 510,00 CZK |
About This Item
Empirical Formula (Hill Notation):
C19H25N5
CAS Number:
Molecular Weight:
323.44
UNSPSC Code:
12352200
NACRES:
NA.77
Form:
powder
Product Name
S3QEL 2,
form
powder
Quality Segment
color
white to beige
solubility
DMSO: 5 mg/mL, clear
storage temp.
−20°C
Biochem/physiol Actions
S3QEL 2 is a selective inhibitor of superoxide production from the outer Q-binding site of mitochondrial respiratory complex site III (IIIQo) without altering oxidative phosphorylation.
S3QEL 2 is a selective inhibitor of superoxide production from the outer Q-binding site of mitochondrial respiratory complex site III (IIIQo) without altering oxidative phosphorylation. Site IIIQo is the primary source of mitochondrial reactive oxygen species (ROS) and has been implicated in a broad range of ROS-mediated signaling and pathology. S3QEL 2 lowered HIF-1α induction, protected against ROS-induced, JNK-mediated cell stress in pancreatic beta-cells, and decreased the oxidative stress-induced apoptosis that limits the yield of functional β-cells from intact islets.
S3QEL 2, a cell permeable substituted allopurinol, is also known as 1-(3,4-Dimethylphenyl)-N,N-dipropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine.
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This Item | |||
|---|---|---|---|
| description - | description ≥98% (HPLC) | description ≥98% (HPLC) | description ≥98% (HPLC) |
| form powder | form powder | form powder | form powder |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. −20°C | storage temp. 2-8°C | storage temp. −20°C | storage temp. room temp |
| solubility DMSO: 5 mg/mL, clear | solubility DMSO: 10 mg/mL, clear | solubility DMSO: 2 mg/mL, clear | solubility DMSO: >20 mg/mL |
| color white to beige | color white to beige | color white to beige | color white to off-white |
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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