This product has not been tested for suitability in animal models. However, the following link references the use of HS-72 in a mouse model.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4272656/
SML1325
HS-72
≥98% (HPLC)
Synonym(s):
(S)-N-(1-propyl-1H-benzimidazol-2-yl)-1-(2-pyrazinyl)-3-Piperidinecarboxamide
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| Size/SKU | Availability | Price |
|---|---|---|
5 mg | Please contact Customer Service for Availability | 3 650,00 CZK 3 102,50 CZK |
About This Item
Empirical Formula (Hill Notation):
C20H24N6O
Molecular Weight:
364.44
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
powder
3 102,50 CZK
List Price3 650,00 CZKSave 15%Web-Only Promotion
Please contact Customer Service for Availability
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 5 mg/mL, clear (warmed)
storage temp.
2-8°C
Biochem/physiol Actions
HS-72 is a cell permeable, highly selective allosteric inhibitor of inducible Hsp70 (Hsp70i) over constitutively active Hsc70. HS-72 inhibits cancer cell proliferation and promotes a survival in a HER2+ mouse model of breast cancer.
HS-72 is a cell permeable, highly selective allosteric inhibitor of inducible Hsp70 (Hsp70i).
HS-72 is also termed as ((S)-N-(1-propyl-1H-benzo[d]imidazol-2-yl)-1-(pyrazin-2-yl)piperidine-3-carboxamide). It is considered as a powerful anti-dengue virus (DENV) therapeutic agent. It displays anti-DENV activity in monocyte and liver cell lines. HS-72 stimulates the accumulation of cellular proteins.
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This Item | |||
|---|---|---|---|
| description ≥98% (HPLC) | description ≥98% (HPLC) | description ≥98% (HPLC) | description ≥98% (HPLC) |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| form powder | form powder | form powder | form powder |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility DMSO: 5 mg/mL, clear (warmed) | solubility DMSO: 2 mg/mL, clear (Warmed) | solubility DMSO: 2 mg/mL, clear | solubility DMSO: 15 mg/mL, clear |
| color white to beige | color white to beige | color white to beige | color , white to beige to brown |
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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I couldn't find any studies using HS-72 in rats. If possible, could you provide information about the dosage?
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