This material can be dissolved in dimethyl sulfoxide (DMSO) at a concentration of 5 mg/mL, with warming. Case C25246106 mentioned it can also be dissolved in a solution containing 1% DMSO, 30% polyethylene glycol, and 1% Tween 80 at the same concentration of 5 mg/mL.
SML1312
Mubritinib
≥98% (HPLC)
Synonym(s):
(E)-4-((4-(4-(1H-1,2,3-triazol-1-yl)butyl)phenoxy)methyl)-2-(4-(trifluoromethyl)styryl)oxazole, 1-[4-[4-[[2-[(1E)-2-[4-(Trifluoromethyl)phenyl]ethenyl]-4-oxazolyl]methoxy]phenyl]butyl]-1H-1,2,3-triazole, CID 6444692, TAK 165, TAK-165
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| Size/SKU | Availability | Price |
|---|---|---|
5 mg | Please contact Customer Service for Availability | 1 860,00 CZK |
25 mg | Please contact Customer Service for Availability | 7 210,00 CZK |
About This Item
Empirical Formula (Hill Notation):
C25H23F3N4O2
CAS Number:
Molecular Weight:
468.47
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 5 mg/mL, clear (warmed)
storage temp.
2-8°C
SMILES string
FC(F)(F)C1=CC=C(/C=C/C2=NC(COC3=CC=C(C=C3)CCCCN4C=CN=N4)=CO2)C=C1
InChI
1S/C25H23F3N4O2/c26-25(27,28)21-9-4-20(5-10-21)8-13-24-30-22(18-34-24)17-33-23-11-6-19(7-12-23)3-1-2-15-32-16-14-29-31-32/h4-14,16,18H,1-3,15,17H2/b13-8+
InChI key
ZTFBIUXIQYRUNT-MDWZMJQESA-N
Gene Information
human ... ERBB2(2064)
Biochem/physiol Actions
Mubritinib (TAK-165) is a potent and selective inhibitor of ErbB-2 (HER2).
Mubritinib (TAK-165) is a potent and selective inhibitor of the human epidermal growth factor receptor 2 ErbB (HER2) tyrosine kinase. Mubritinib potently inhibits proliferation of cancer cell lines over- expressing ErbB2.
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This Item | |||
|---|---|---|---|
| description ≥98% (HPLC) | description ≥98% (HPLC) | description ≥98% (HPLC) | description ≥98% (HPLC) |
| form powder | form powder | form powder | form powder |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility DMSO: 5 mg/mL, clear (warmed) | solubility DMSO: 10 mg/mL, clear | solubility DMSO: 15 mg/mL, clear | solubility DMSO: 20 mg/mL, clear |
| color white to beige | color white to beige | color white to beige | color white to beige |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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What solvents are recommended for dissolving Mubritinib (SML1312) for in vivo experiments?
1 answer-
Helpful?
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what solvents should be used to dissolve Mubritinib (SML1312) for in vivo experiments.
1 answer-
This material can be dissolved in dimethyl sulfoxide (DMSO) at 5 mg/mL, with warming.
Helpful?
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