Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
| Size/SKU | Availability | Price |
|---|---|---|
5 mg | Please contact Customer Service for Availability | 3 780,00 CZK |
25 mg | Please contact Customer Service for Availability | 14 900,00 CZK |
About This Item
Empirical Formula (Hill Notation):
C14H12ClN3O4S2
CAS Number:
Molecular Weight:
385.85
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Product Name
Indisulam, ≥98% (HPLC)
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to pink
solubility
DMSO: 20 mg/mL, clear
storage temp.
−20°C
SMILES string
ClC1=CNC2=C1C=CC=C2NS(C3=CC=C(S(=O)(N)=O)C=C3)(=O)=O
InChI
1S/C14H12ClN3O4S2/c15-12-8-17-14-11(12)2-1-3-13(14)18-24(21,22)10-6-4-9(5-7-10)23(16,19)20/h1-8,17-18H,(H2,16,19,20)
InChI key
SETFNECMODOHTO-UHFFFAOYSA-N
Biochem/physiol Actions
Indisulam is a carbonic anhydrase inibitor and Antitumor CDK inhibitor.
Indisulam is a carbonic anhydrase inibitor and Antitumor CDK inhibitor. Indisulam targets the G1 phase of the cell cycle by depleting cyclin E. inducing p53 and p21, and inhibiting CDK2, causing a blockade in the G1/S transition.
Indisulam is synthetic sulfonamide compound. In vitro and in vivo studies point out that indisulam prevents retinoblastoma protein phosphorylation. Also, it inhibits cyclins A and B1 activity. Indisulam is known to promote apoptosis. Indisulam is a potent inhibitor of cellular dehydrogenases and thus, is likely to interfere with metabolic pathways such as malate-aspartate shuttle, glycolysis and gluconeogenesis.
1 of 1
This Item | ||
|---|---|---|
| description ≥98% (HPLC) | description ≥98% (HPLC) | description foil, 6mm disks, thickness 0.1mm, as rolled, 100% |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay 100% |
| form powder | form powder | form foil |
| Quality Level 100 | Quality Level 100 | Quality Level - |
| storage temp. −20°C | storage temp. 2-8°C | storage temp. - |
| solubility DMSO: 20 mg/mL, clear | solubility DMSO: 2 mg/mL, clear | solubility - |
| color white to pink | color white to beige | color - |
Signal Word
Warning
Hazard Codes
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.



