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SML1225

Indisulam

≥98% (HPLC), carbonic anhydrase inibitor, powder

Synonym(s):

N-(3-chloro-1H-indol-7-yl)-4-sulfamoylbenzenesulfonamide, N1-(3-Chloro-1H-indol-7-yl)-1,4-benzenedisulfonamide

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Size/SKUAvailabilityPrice
5 mg
Please contact Customer Service for Availability
3 780,00 CZK
25 mg
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14 900,00 CZK

About This Item

Empirical Formula (Hill Notation):
C14H12ClN3O4S2
CAS Number:
Molecular Weight:
385.85
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder

3 780,00 CZK


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Product Name

Indisulam, ≥98% (HPLC)

Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to pink

solubility

DMSO: 20 mg/mL, clear

storage temp.

−20°C

SMILES string

ClC1=CNC2=C1C=CC=C2NS(C3=CC=C(S(=O)(N)=O)C=C3)(=O)=O

InChI

1S/C14H12ClN3O4S2/c15-12-8-17-14-11(12)2-1-3-13(14)18-24(21,22)10-6-4-9(5-7-10)23(16,19)20/h1-8,17-18H,(H2,16,19,20)

InChI key

SETFNECMODOHTO-UHFFFAOYSA-N

Biochem/physiol Actions

Indisulam is a carbonic anhydrase inibitor and Antitumor CDK inhibitor.
Indisulam is a carbonic anhydrase inibitor and Antitumor CDK inhibitor. Indisulam targets the G1 phase of the cell cycle by depleting cyclin E. inducing p53 and p21, and inhibiting CDK2, causing a blockade in the G1/S transition.
Indisulam is synthetic sulfonamide compound. In vitro and in vivo studies point out that indisulam prevents retinoblastoma protein phosphorylation. Also, it inhibits cyclins A and B1 activity. Indisulam is known to promote apoptosis. Indisulam is a potent inhibitor of cellular dehydrogenases and thus, is likely to interfere with metabolic pathways such as malate-aspartate shuttle, glycolysis and gluconeogenesis.

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This Item
SML2952GF29634228
description

≥98% (HPLC)

description

≥98% (HPLC)

description

foil, 6mm disks, thickness 0.1mm, as rolled, 100%

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

100%

form

powder

form

powder

form

foil

Quality Level

100

Quality Level

100

Quality Level

-

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

-

solubility

DMSO: 20 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

-

color

white to pink

color

white to beige

color

-


Pictograms

Exclamation mark

Signal Word

Warning

Hazard Codes

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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