SML1186

GGTI-286 dihydrochloride

≥90% (HPLC)

• Synonym(s): (R)-N-[[5-[(2-Amino-3-mercaptopropyl)amino][1,1′-biphenyl]-2-yl]carbonyl]-L-lLeucine methyl ester dihydrochloride, GGTI 286 dihydrochloride, N-[[5-[[(2R)-2-Amino-3-mercaptopropyl]amino][1,1′-biphenyl]-2-yl]carbonyl]-L-leucine methyl ester dihydrochloride
• Empirical Formula (Hill Notation): C₂₃H₃₁N₃O₃S · 2HCl
• CAS Number: 171744-11-9
• Molecular Weight: 502.50
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥90% (HPLC)
• Form: powder
• Storage condition: desiccated

Properties

• assay: ≥90% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to light brown
• solubility: DMSO: 20 mg/mL, clear
• shipped in: wet ice
• storage temp.: −20°C
• SMILES string: SC[C@H](N)CNc1cc(c(cc1)C(=O)N[C@@H](CC(C)C)C(=O)OC)c2ccccc2
• InChI key: IENQPUVVSDIXCT-UTKZUKDTSA-N

Description

Biochem/physiol Actions

GGTI-286 is a cell permeable, potent and selective inhibitor of geranylgeranyltransferase I (GGTase I) that selectively disrupts oncogenic K-Ras4B. New study shows that GGTI-286 reduces nuclear localization of β-catenin.

GGTI-286 is a cell permeable, potent and selective inhibitor of geranylgeranyltransferase I (GGTase I). CAAX peptidomimetic.

Other Notes

Air sensitive; dessicant.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Codes: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable