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SML1160

CD40-TRAF6 signaling inhibitor

≥98% (HPLC)

Synonym(s):

3-[(2,5-Dimethylphenyl)amino]-1-phenyl-2-propen-1-one, Compound 6877002

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Size/SKUAvailabilityPrice
5 mg
Please contact Customer Service for Availability
2 550,00 CZK
2 167,50 CZK
25 mg
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8 070,00 CZK
6 859,50 CZK

About This Item

Empirical Formula (Hill Notation):
C17H17NO
CAS Number:
433249-94-6
Molecular Weight:
251.32
UNSPSC Code:
51111800
PubChem Substance ID:
329825690
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder

2 167,50 CZK

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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(C1=CC=CC=C1)/C=N/C2=CC(C)=CC=C2C

InChI

1S/C16H15NO/c1-12-8-9-13(2)15(10-12)17-11-16(18)14-6-4-3-5-7-14/h3-11H,1-2H3/b17-11+

InChI key

WIFPLULEUNBSTE-GZTJUZNOSA-N

Application

CD40-TRAF6 signaling inhibitor has been used to treat human embryonic kidney (HEK)-293T cells to test its inhibitory effect on the tumor necrosis factor receptor (TNFR)-associated factor 6 (TRAF6) leading to subsequent abrogation of (P2RY6)-dependent nuclear factor kappa B (NF-κB).

Biochem/physiol Actions

CD40-TRAF6 signaling inhibitor is a small molecule that binds to TRAF6, blocking interactions with CD40.
CD40-TRAF6 signaling inhibitor is a small molecule that binds to TRAF6, blocking interactions with CD40. The compound inhibits CD40-induced production of IL-1b and IL-6 in primary macrophages. The compound reduces insulin resistance and adipose tissue inflammation in a mouse diet induced obesity model.
CD40-TRAF6 (cluster of differentiation 40-TNF receptor associated factor) signaling is recognized as an effective target in treating vascular disease.

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This Item
EMU046421SAB3500377RAB0086
CD40-TRAF6 signaling inhibitor ≥98% (HPLC)

Sigma-Aldrich

SML1160

CD40-TRAF6 signaling inhibitor

MISSION® esiRNA targeting mouse Traf6

Sigma-Aldrich

EMU046421

MISSION® esiRNA

Anti-TRAF6 antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution

Sigma-Aldrich

SAB3500377

Anti-TRAF6 antibody produced in rabbit

Mouse CD40 ELISA Kit for serum, plasma and cell culture supernatant

Sigma-Aldrich

RAB0086

Mouse CD40 ELISA Kit

description

≥98% (HPLC)

description

targeting mouse Traf6

description

IgG fraction of antiserum, buffered aqueous solution

description

for serum, plasma and cell culture supernatant

form

powder

form

lyophilized powder

form

buffered aqueous solution

form

-

assay

≥98% (HPLC)

assay

-

assay

-

assay

-

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

solubility

DMSO: 20 mg/mL, clear

solubility

-

solubility

-

solubility

-

color

white to beige

color

-

color

-

color

-

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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