SML1139

Rostafuroxin

≥98% (HPLC)

• Synonym(s): (3,5,14)-21,23-epoxy24-Norchola-20,22-diene-3,14,17-triol, PST 2238
• Empirical Formula (Hill Notation): C₂₃H₃₄O₄
• CAS Number: 156722-18-8
• Molecular Weight: 374.51
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: −20°C
• SMILES string: [o]1cc(cc1)[C@@]2([C@@]3([C@@]([C@H]4[C@@H]([C@@]5([C@@H](C[C@H](CC5)O)CC4)C)CC3)(CC2)O)C)O
• InChI: 1S/C23H34O4/c1-20-8-5-17(24)13-15(20)3-4-19-18(20)6-9-21(2)22(25,10-11-23(19,21)26)16-7-12-27-14-16/h7,12,14-15,17-19,24-26H,3-6,8-11,13H2,1-2H3/t15-,17+,18+,19-,20+,21-,22+,23+/m1/s1
• InChI key: AEAPORIZZWBIEX-DTBDINHYSA-N

Description

Biochem/physiol Actions

Rostafuroxin is a Na-K ATPase; Ouabain antagonist.

Rostafuroxin is a digitoxygenin derivative that selectively antagonizes the effects of endogenous ouabain on the Na⁺,K⁺-ATPase, which maintains sodium and potassium ion gradients across plasma membranes. Rostafuroxin lowers blood pressure (BP) in animal models of hypertension.

Rostafuroxin is a derivative of digitoxigenin. It protects animal models against podocyte lesions and proteinuria by counteracting mutant β-adducin and ouabain-mediated effects.

Safety Information

• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable