The solubility of Atglistatin is validated at a concentration of 20 mg/mL in DMSO yielding a clear solution. Further dilutions into aqueous solutions, such as cell culture media or PBS, are not validated and would have to be evaluated by the end-user.
SML1075
Atglistatin
≥98% (HPLC), powder, adipose triglyceride lipase inhibitor
Synonym(s):
3-(4′-(Dimethylamino)-[1,1′-biphenyl]-3-yl)-1,1-dimethylurea
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| Size/SKU | Availability | Price |
|---|---|---|
5 mg | Please contact Customer Service for Availability | 3 880,00 CZK |
25 mg | Please contact Customer Service for Availability | 12 400,00 CZK 10 540,00 CZK |
About This Item
Empirical Formula (Hill Notation):
C17H21N3O
CAS Number:
Molecular Weight:
283.37
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Product Name
Atglistatin, ≥98% (HPLC)
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 20 mg/mL, clear
storage temp.
2-8°C
SMILES string
CN(C)C(NC1=CC=CC(C2=CC=C(N(C)C)C=C2)=C1)=O
InChI
1S/C17H21N3O/c1-19(2)16-10-8-13(9-11-16)14-6-5-7-15(12-14)18-17(21)20(3)4/h5-12H,1-4H3,(H,18,21)
InChI key
AWOPBSAJHCUSAS-UHFFFAOYSA-N
Application
Biochem/physiol Actions
Atglistatin is a selective inhibitor of adipose triglyceride lipase (ATGL).
Atglistatin is the first selective inhibitor of adipose triglyceride lipase (ATGL), the rate limiting enzyme involved in the mobilization of fatty acids from cellular triglyceride stores. Atglistatin has an IC50 of 0.7 μM in E.coli and no activity against monoglycerol lipase (MGL), hormone-sensitive lipase (HSL), or pancreatic lipase and lipoprotein lipase PNPLA6 and PNPLA7. ATGL generates diacylglycerol from cellular triglyceride stores, which is then degraded by hormone-sensitive lipase (HSL) and monoglyceride lipase into glycerol and fatty acids, promoting the synthesis of lipotoxic metabolites that have been associated with the development of insulin resistance. Atglistatin inhibition of ATGL has been shown to reduce fatty acid mobilization in vitro and in vivo.
Other Notes
Produced under the license of University of Graz/Graz University of Technolog
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This Item | |||
|---|---|---|---|
| description ≥98% (HPLC) | description ≥98% (HPLC) | description ≥98% (HPLC) | description ≥98% (HPLC) |
| form powder | form powder | form powder | form powder |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. −20°C | storage temp. 2-8°C |
| solubility DMSO: 20 mg/mL, clear | solubility DMSO: 10 mg/mL, clear | solubility DMSO: 20 mg/mL, clear | solubility DMSO: 20 mg/mL, clear |
| color white to beige | color white to beige | color white to beige | color white to beige |
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Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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Can cell media/PBS be used as a diluent for stock solutions of Atglistatin for an in-vitro treatment paradigm?
1 answer-
Helpful?
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How long do stock and working solutions of ATGListatin last when stored in 2-8*C?
1 answer-
The stability of stock solutions at 2-8°C has not been determined. Following reconstitution, solutions in DMSO may be aliquoted and frozen at -20°C for up to 6 months. Various external sources indicate stock solutions prepared in Ethanol may be stored at -20°C for up to 3 months. This information has not been validated.
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