SML1058

PBIT

≥98% (HPLC)

• Synonym(s): 2-(4-Methylphenyl)-1,2-benzisothiazol-3(2H)-one; 2-(4-Methylphenyl)-2,3-dihydrobenzisothiazol-3-one, 2-p-Tolyl-1,2-benzisothiazolin-3-one
• Empirical Formula (Hill Notation): C₁₄H₁₁NOS
• CAS Number: 2514-30-9
• Molecular Weight: 241.31
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 10 mg/mL, clear (warmed)
• storage temp.: 2-8°C
• SMILES string: [s]1[n]([c](c3c1cccc3)=O)c2ccc(cc2)C
• InChI: 1S/C14H11NOS/c1-10-6-8-11(9-7-10)15-14(16)12-4-2-3-5-13(12)17-15/h2-9H,1H3
• InChI key: KRXMYBAZKJBJAB-UHFFFAOYSA-N

Description

Biochem/physiol Actions

PBIT is a potent inhibitor of JARID1B (KDM5B) histone lysine demethylase that inhibits removal of H3K4me3 in UACC-812 cells. PBIT inhibits proliferation of cells overexpressing JARID1B. PBIT is selective for JARID1 enzymes and does not inhibit demethylases UTX or JMJD3.

PBIT is a potent inhibitor of JARID1B (KDM5B).

S,S′-1,4-phenylenebis(1,2-ethanediyl)bis-isothiourea (PBIT) is an iNOS (inducible nitric oxide synthase) inhibito. It is capable of inhibiting the multiplication of breast cancer cell lines expressing high levels of JARIDB1.

Features and Benefits

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Safety Information

• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable