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SML0927

Diapocynin

≥98% (HPLC)

Synonym(s):

1,1′-(6,6′-Dihydroxy-5,5′-dimethoxy[1,1′-biphenyl]-3,3′-diyl)bis-ethanone, 4′,4′′′-Dihydroxy-5′,5′′′-dimethoxy-3′,3′′′-biacetophenone (8CI), Dehydrodiacetovanillone

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About This Item

Empirical Formula (Hill Notation):
C18H18O6
CAS Number:
Molecular Weight:
330.33
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
powder
Quality level:


Quality Level

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

room temp

Biochem/physiol Actions

Diapocynin, a proposed NADPH oxidase (NOX) inhibitor, is an anti-inflammatory and antioxidant agent.
Diapocynin, a proposed NADPH oxidase (NOX) inhibitor, is an anti-inflammatory and antioxidant agent. Diapocynin attenuates oxidative damage and neuroinflammatory responses in animal model of Parkinson′s disease. Diapocynin reverses deficient motor coordination in LRRK2R1441Gtg mice of PD.
Diapocynin is a covalent dimer of apocynin, and a functional metabolite of the same. It is generated by neutrophil activation via myeloperoxidase-mediated oxidation. Studies show that diapocynin has greater neuroprotection compared to apocynin.

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This Item
SML1533SML3593693014
assay

≥98% (HPLC)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

-

form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

room temp

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

-

solubility

DMSO: 2 mg/mL, clear (warmed)

solubility

DMSO: 20 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

-

color

white to beige

color

light yellow to dark yellow

color

white to beige

color

-


pictograms

Environment

signalword

Warning

hcodes

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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Articles

DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research


Diapocynin and apocynin administration fails to significantly extend survival in G93A SOD1 ALS mice
Trumbull KA, et al.
Neurobiology of Disease, 45(1), 137-144 (2012)
Sclerosis: New Insights for the Healthcare Professional, 25-25 (2012)



Global Trade Item Number

SKUGTIN
SML0927-5MG04061833224366
SML0927-25MG04061833224359

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