SML0902

MONNA

Name: MONNA
Brand: SIGMA
Price: 2620 CZK

≥98% (HPLC)

Synonym(s):

N-((4-Methoxy)-2-naphthyl)-5-nitroanthranilic acid

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5 MG

CZK 2,620.00

25 MG

CZK 10,200.00

CZK 2,620.00

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About This Item

Empirical Formula (Hill Notation):

C₁₈H₁₄N₂O₅

Molecular Weight:

338.31

NACRES:

NA.77

UNSPSC Code:

12352200

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

Key Documents

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Quality Level

100

assay

≥98% (HPLC)

form

powder

color

light orange to dark orange

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

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Show Differences

1 of 4

This Item	SML2754	SML2983	SML1733
Sigma-Aldrich SML0902 MONNA	Sigma-Aldrich SML2754 Z3670677764	Sigma-Aldrich SML2983 Vandetanib	Sigma-Aldrich SML1733 FINDY
form powder	form powder	form powder	form powder
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
solubility DMSO: 20 mg/mL, clear	solubility DMSO: 2 mg/mL, clear	solubility DMSO: 2 mg/mL, clear	solubility DMSO: 25 mg/mL, clear
color light orange to dark orange	color white to beige	color white to beige	color light yellow to dark yellow

Biochem/physiol Actions

MONNA is a TMEM16A (ANO1) calcium-activated chloride channel blocker.

MONNA is a TMEM16A (ANO1) calcium-activated chloride channel blocker. MONNA blocks rhTMEM16A (ANO1) channel currents in HEK293 cells with and IC₅₀ of 1.27 μM. The compound MONNA does not affect related human or mouse chloride channels bestrophin-1, CLC2 and CFTR at concentrations up to 10 μM.

MONNA (benzbromarone (Benzb) and N-((4-methoxy)-2-naphthyl)-5-nitroanthranilic acid) is a TMEM16A antagonists. It affects the liberation of sarcoplasmic reticulum (SR) calcium in human airway smooth muscle cells.

pictograms

GHS07

signalword

Warning

hcodes

H302,H315,H319,H335

pcodes

P261 - P264 - P271 - P301 + P312 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Antagonists of the TMEM16A calcium-activated chloride channel modulate airway smooth muscle tone and intracellular calcium.

Danielsson J, et al.

Anesthesiology, 123(3), 569-581 (2015)

Ceramide-Induced Cell Death Depends on Calcium and Caspase-Like Activity in Rice.

Quan-Fang Zhang et al.

Frontiers in plant science, 11, 145-145 (2020-03-13)

Ceramide sphingolipids are major components of membranes. C2 and C6 ceramides induce programmed cell death (PCD) in animals and plants, and we previously showed that C2 and C6 ceramides induce PCD in rice (Oryza sativa) protoplasts. However, the mechanistic link

TMEM16A/ANO1 calcium-activated chloride channel as a novel target for the treatment of human respiratory syncytial virus infection.

Hayley Pearson et al.

Thorax, 76(1), 64-72 (2020-10-29)

Human respiratory syncytial virus (HRSV) is a common cause of respiratory tract infections (RTIs) globally and is one of the most fatal infectious diseases for infants in developing countries. Of those infected, 25%-40% aged ≤1 year develop severe lower RTIs leading to

Global Trade Item Number

SKU	GTIN
SML0902-25MG	04061832576640
SML0902-5MG	04061832576657

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MONNA