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SML0885

bpV(pic)

≥95% V basis

Synonym(s):

Dipotassium Bisperoxovanadium(pic) dihydrate, Dipotassium bisperoxo (picolinato) oxovanadate (V) dihydrate, K2 [VO(O2)2C6H4NO2] · 2 H2O

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Size/SKUAvailabilityPrice
5 mg
Please contact Customer Service for Availability
2 600,00 CZK
25 mg
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9 270,00 CZK

About This Item

Empirical Formula (Hill Notation):
K2VOO2O2C6H4NO2 · 2H2O
CAS Number:
Molecular Weight:
367.27
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥95% V basis
Form:
powder
Storage condition:
protect from light

2 600,00 CZK


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Quality Segment

assay

≥95% V basis

form

powder

storage condition

protect from light

color

faintly yellow to dark yellow

solubility

H2O: 20 mg/mL, clear

storage temp.

−20°C

Application

bpV(pic) has been used in cell culture treatment to study the route of activation of multiple pathways required for HERV (human endogenous retroviruses) transcription.

Biochem/physiol Actions

bpV(pic) is a bisperoxovanadium inhibitor of protein phosphotyrosine phosphatases with selectivity for phosphatase and tensin homolog (PTEN), a tumour suppressor phosphatase involved in cell cycle regulation. IC50 values for bpV(pic) are 31 nM for PTEN compared to 12.7 μM for PTPβ and 61 μM for PTP-1β. bpV(pic) can also act as an insulin mimetic and activate insulin receptor kinase (IRK).
bpV(pic) is a bisperoxovanadium inhibitor of protein phosphotyrosine phosphatases with selectivity for phosphatase and tensin homolog (PTEN).
bpV(pic) contains a polar side chain, and specifically inhibits PTEN(phosphatase and tensin homolog) unlike its parent compound, which targets several other phosphatases too. Thus, making bpV(pic) more a prefered inhibitor. bpV(pic) is recognized as a potent activator of multiple sclerosis (an autoimmune disorder) related human endogenous retroviruses.

Other Notes

Light Sensitive

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This Item
SML0884SML0889203694
description

≥95% V basis

description

≥90% V basis

description

≥95% V basis

description

A potent inhibitor of phosphotyrosine phosphatase (Ki = 100 nM for insulin receptor dephosphorylation).

form

powder

form

powder

form

powder

form

solid

assay

≥95% V basis

assay

≥90% V basis

assay

≥95% V basis

assay

≥95% (51V-NMR)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage condition

protect from light

storage condition

desiccated, protect from light

storage condition

protect from light

storage condition

protect from light, OK to freeze

solubility

H2O: 20 mg/mL, clear

solubility

H2O: 20 mg/mL, clear

solubility

H2O: 20 mg/mL, clear

solubility

water: 5 mg/mL


pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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