SML0822
YM-08
≥98% (HPLC)
Synonym(s):
3-Ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-2-(2-pyridinylmethylene)-4-thiazolidinone
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| Size/SKU | Availability | Price |
|---|---|---|
5 mg | Please contact Customer Service for Availability | 4 150,00 CZK 3 527,50 CZK |
25 mg | Please contact Customer Service for Availability | 16 800,00 CZK 14 280,00 CZK |
About This Item
Empirical Formula (Hill Notation):
C19H17N3OS2
CAS Number:
Molecular Weight:
367.49
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
powder
3 527,50 CZK
List Price4 150,00 CZKSave 15%Web-Only Promotion
Please contact Customer Service for Availability
Biochem/physiol Actions
YM-08 is a Heat Shock Protein 70 (Hsp70) inhibitor that is blood-brain barrier permeable. YM-08 is a neutral derivative of the Hsp70 inhibitor MKT-077. MKT-077 reduces tau levels in cellular models, but it doesn′t penetrate the blood brain barrier. Although YM-08 was somewhat less effective than MKT-077 in anti-tau and anticancer assays, it selectively reduced pathogenic tau in brain slices, which MKT-077 did not. Furthermore,YM-08 was not retained in the kidney leading one to speculate that it would not have the nephrotoxicity that was a problem for MKT-077 in clinical trials.
YM-08 is a Heat Shock Protein 70 inhibitor that is blood-brain barrier permeable.
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This Item | |||
|---|---|---|---|
| description ≥98% (HPLC) | description - | description ≥98% (HPLC), powder | description ≥98% (HPLC) |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| form powder | form powder | form powder | form powder |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| color yellow to orange | color orange to dark red | color orange to red | color yellow to orange-brown |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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