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Merck

SML0806

7DG

≥95% (HPLC)

Synonym(s):

7-Desacetoxy-6,7-dehydrogedunin

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About This Item

Empirical Formula (Hill Notation):
C26H30O5
CAS Number:
26927-01-5
Molecular Weight:
422.51
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥95% (HPLC)
Form:
powder
Quality level:
100

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Quality Level

100

assay

≥95% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL, clear

shipped in

wet ice

storage temp.

2-8°C

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This Item
361549521234288104
7DG ≥95% (HPLC)

Sigma-Aldrich

SML0806

7DG

GSK-3β Inhibitor VIII The GSK-3β Inhibitor VIII, also referenced under CAS 487021-52-3, controls the biological activity of GSK-3β. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Sigma-Aldrich

361549

GSK-3β Inhibitor VIII

PDGFR Tyrosine Kinase Inhibitor V The PDGFR Tyrosine Kinase Inhibitor V, also referenced under CAS 347155-76-4, controls the biological activity of PDGFR Tyrosine Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Sigma-Aldrich

521234

PDGFR Tyrosine Kinase Inhibitor V

2′,5′-Dideoxyadenosine Cell-permeable, non-competitive adenylate cyclase inhibitor (IC50 = 3 µM), that binds to the adenosine P1 binding site.

Sigma-Aldrich

288104

2′,5′-Dideoxyadenosine

form

powder

form

solid

form

solid

form

solid

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 5 mg/mL, clear

solubility

DMSO: 5 mg/mL

solubility

DMSO: 25 mg/mL

solubility

DMSO: 10 mg/mL

shipped in

wet ice

shipped in

ambient

shipped in

ambient

shipped in

ambient

General description

7-Desacetoxy-6,7-dehydrogedunin (7DG) is structurally similar to HSP90 (heat shock protein 90) inhibitor, also known as gedunin.[1]

Biochem/physiol Actions

7-Desacetoxy-6,7-dehydrogedunin (7DG) is a selective inhibitor of protein kinase R (PKR).
7-Desacetoxy-6,7-dehydrogedunin (7DG) is a selective inhibitor of protein kinase R (PKR). 7DG appears to directly interact with the C-terminal half of PKR, and unlike C16, does not bind the ATP catalytic pocket. 7-Desacetoxy-6,7-dehydrogedunin completely protected macrophages from anthrax lethal toxin (LT)-induced pyroptotic cell death, a model for inflammasome-mediated caspase-1 activation, with an (IC50) of 5 μM, showing a role for PKR in pyroptosis.

Features and Benefits

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000037388
0000037387
0000036375
0000021379
0000021278

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Erik C Hett et al.
Nature chemical biology, 9(6), 398-405 (2013-04-23)
Formation of the inflammasome, a scaffolding complex that activates caspase-1, is important in numerous diseases. Pyroptotic cell death induced by anthrax lethal toxin (LT) is a model for inflammasome-mediated caspase-1 activation. We discovered 7-desacetoxy-6,7-dehydrogedunin (7DG) in a phenotypic screen as

Articles

Inhibitory a aktivátory kaspáz

Mezi látky, které aktivují buněčné kaspázy, patří chemoterapeutika, agonisté receptoru TNF a další enzymy. Inhibitory apoptózy byly prvními identifikovanými endogenními inhibitory kaspáz.

Caspases Inhibitors and Activators

Agents reported to activate cellular caspases include chemotherapeutic drugs, TNF receptor agonists, and other enzymes. Inhibitors of apoptosis were the first identified endogenous caspase inhibitors.

Global Trade Item Number

SKUGTIN
SML0806-5MG04061832451022
SML0806-1MG04061826132548

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