SML0805

CID16020046

≥98% (HPLC)

• Synonym(s): 4-[4,6-Dihydro-4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxopyrrolo[3,4-c]pyrazol-5(1H)-yl]-benzoic acid
• Empirical Formula (Hill Notation): C₂₅H₁₉N₃O₄
• CAS Number: 834903-43-4
• Molecular Weight: 425.44
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 1 mg/mL, clear (warmed)
• storage temp.: 2-8°C
• SMILES string: [nH]1nc(c3c1C(=O)N(C3c5cc(ccc5)O)c4ccc(cc4)C(=O)O)c2ccc(cc2)C
• InChI: 1S/C25H19N3O4/c1-14-5-7-15(8-6-14)21-20-22(27-26-21)24(30)28(18-11-9-16(10-12-18)25(31)32)23(20)17-3-2-4-19(29)13-17/h2-13,23,29H,1H3,(H,26,27)(H,31,32)
• InChI key: VGUQVYZXABOXCX-UHFFFAOYSA-N

Description

Application

CID16020046 has been used as an antagonist of G-protein coupled receptor (GPR55) to test its effect on nociceptive behavior in rats induced with formalin.

Biochem/physiol Actions

CID16020046 is a potent and a selective GPR55 antagonist that inhibits GPR55-mediated ERK1/2 phosphorylation. CID16020046 inhibits LPI-induced Ca²⁺ signaling in HEK-GPR55 cells.

CID16020046 is a potent and a selective GPR55 antagonist.

Safety Information

• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable