SML0773

GSK-650394

≥98% (HPLC)

• Synonym(s): 2-Cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-benzoic acid, GSK 650394, GSK650394
• Empirical Formula (Hill Notation): C₂₅H₂₂N₂O₂
• CAS Number: 890842-28-1
• Molecular Weight: 382.45
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: room temp
• SMILES string: [nH]1c2ncc(cc2c(c1)c4cc(c(cc4)C(=O)O)C5CCCC5)c3ccccc3
• InChI: 1S/C25H22N2O2/c28-25(29)20-11-10-18(12-21(20)17-8-4-5-9-17)23-15-27-24-22(23)13-19(14-26-24)16-6-2-1-3-7-16/h1-3,6-7,10-15,17H,4-5,8-9H2,(H,26,27)(H,28,29)
• InChI key: WVSBGSNVCDAMCF-UHFFFAOYSA-N

Description

Application

GSK-650394 has been used as a serum and glucocorticoid-activated kinase (SGK1) inhibitor.

Biochem/physiol Actions

GSK-650394 has an IC₅₀ value of 62 nM for serum and glucocorticoid-activated kinase-1 (SGK1) and 103 nM for SGK2.[1] It has an ability to stop viral replication at concentrations that are nontoxic to cells.[1]

GSK-650394 is a potent and selective Serum- and glucocorticoid-regulated kinase 1 (SGK1) antagonist.

GSK-650394 is a potent, selective SGK1 antagonist.

Features and Benefits

This compound is featured on the PKB/Akt page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable