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SML0681

Febrifugine dihydrochloride

≥95% (HPLC)

Synonym(s):

3-[3-[(2R,3S)-3-Hydroxy-2-piperidinyl]-2-oxopropyl]-4(3H)-quinazolinone dihydrochloride

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Size/SKUAvailabilityPrice
5 mg
Please contact Customer Service for Availability
4 530,00 CZK
3 850,50 CZK
25 mg
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18 000,00 CZK

About This Item

Empirical Formula (Hill Notation):
C16H19N3O3 · 2HCl
CAS Number:
32434-42-7
Molecular Weight:
374.26
UNSPSC Code:
51111800
PubChem Substance ID:
329825583
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
powder
Storage condition:
desiccated

3 850,50 CZK

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Quality Segment

assay

≥95% (HPLC)

form

powder

optical activity

[α]/D 10 to 15°, c = 1 in H2O

storage condition

desiccated

color

off-white to gray-brown

solubility

H2O: 15 mg/mL, clear

storage temp.

−20°C

SMILES string

O=C1C2=CC=CC=C2N=CN1CC(C[C@@H]3[C@@H](O)CCCC3)=O.C

InChI

1S/C17H20N2O3.CH4/c20-13(9-12-5-1-4-8-16(12)21)10-19-11-18-15-7-3-2-6-14(15)17(19)22;/h2-3,6-7,11-12,16,21H,1,4-5,8-10H2;1H4/t12-,16+;/m1./s1

InChI key

SNTOTCUGCWLHEZ-KKJWGQAZSA-N

Biochem/physiol Actions

Febrifugine is an antimalarial, the active component of the Chinese herb Chang Shan. Recent studies indicate that its mechanism of action is as an inhibitor of prolyl-transfer RNA synthetase (ProRS).
Febrifugine is an antimalarial, the active component of the Chinese herb Chang Shan; inhibitor of prolyl-transfer RNA synthetase (ProRS).
Febrifugine dihydrochloride exhibits strong antimalarial activity against Plasmodium falciparum, the most insidious malaria causative agent. The adverse effects of febrifugine include diarrhoea, vomiting and liver toxicity.

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This Item
324811133828PHL89387
Febrifugine dihydrochloride ≥95% (HPLC)

Sigma-Aldrich

SML0681

Febrifugine dihydrochloride

Halofuginone hydrobromide VETRANAL®, analytical standard

Supelco

32481

Halofuginone hydrobromide

Cimifugin United States Pharmacopeia (USP) Reference Standard

USP

1133828

Cimifugin

Cimifugin phyproof® Reference Substance

PHL89387

Cimifugin

description

≥95% (HPLC)

description

VETRANAL®, analytical standard

description

United States Pharmacopeia (USP) Reference Standard

description

phyproof® Reference Substance

assay

≥95% (HPLC)

assay

-

assay

-

assay

≥98.0% (HPLC)

form

powder

form

-

form

-

form

-

Quality Level

100

Quality Level

100

Quality Level

-

Quality Level

-

storage temp.

−20°C

storage temp.

-

storage temp.

2-8°C

storage temp.

−20°C

solubility

H2O: 15 mg/mL, clear

solubility

-

solubility

-

solubility

-

storage condition

desiccated

storage condition

-

storage condition

-

storage condition

-

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Codes

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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