SC-514 has been used to study its effect on lipopolysaccharide (LPS)-induced phosphorylation of NF-κB (nuclear factor-κB) p65 and p38 MAPK (mitogen-activated protein kinase).
Biochem/physiol Actions
SC-514 is a cell-permeable, potent and selective ATP competitive inhibitor of nuclear factor kappa-B kinase-2 (IKK-2) that specifically blocks NF-?B-dependent gene expression. SC-514 exhibits anti-inflammatory properties.
SC-514 is a cell-permeable, potent and selective ATP competitive inhibitor of nuclear factor kappa-B kinase-2 (IKK-2).
SC-514 is an amino-acetamide compound. It is selective for IKKβ with an IC50 value of 3−12 μM. SC-514 also inhibits cytokines such as interleukin-6 (IL-6) and IL-8, mediated by IKKβ. IKKβ is responsible for osteoclast survival, hence its inhibition affects osteogenesis.
The IKK-2 Inhibitor, SC-514, also referenced under CAS 354812-17-2, controls the biological activity of IKK-2. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.
description
InSolution, ≥95%
description
-
assay
≥97% (HPLC)
assay
≥95% (HPLC)
assay
≥95% (HPLC)
assay
-
form
powder
form
solid
form
liquid
form
liquid
Quality Level
100
Quality Level
100
Quality Level
100
Quality Level
-
storage temp.
2-8°C
storage temp.
2-8°C
storage temp.
2-8°C
storage temp.
−20°C
solubility
DMSO: 10 mg/mL, clear
solubility
DMSO: 20 mg/mL
solubility
-
solubility
-
color
white to light brown
color
pale yellow
color
clearpale yellow
color
-
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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