SML0503

9(S)-HODE

≥98% (HPLC), metabolite of linoleic acid, solution

• Synonym(s): 9S-Hydroxy-10E,12Z-octadecadienoic acid
• Empirical Formula (Hill Notation): C₁₈H₃₂O₃
• CAS Number: 73543-67-6
• Molecular Weight: 296.44
• NACRES: NA.77
• PubChem Substance ID: 329825451
• UNSPSC Code: 51111800
• EC Number: 200-578-6
• MDL number: MFCD00065831
• Assay: ≥98% (HPLC)
• Form: solution

Properties

• Product Name: 9(S)-HODE, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solution
• concentration: 1 mg/mL in ethanol
• color: colorless to light yellow
• shipped in: wet ice
• storage temp.: −20°C
• SMILES string: CCCCC/C=C\C=C\[C@@H](O)CCCCCCCC(O)=O
• InChI: 1S/C18H32O3/c1-2-3-4-5-6-8-11-14-17(19)15-12-9-7-10-13-16-18(20)21/h6,8,11,14,17,19H,2-5,7,9-10,12-13,15-16H2,1H3,(H,20,21)/b8-6-,14-11+/t17-/m1/s1
• InChI key: NPDSHTNEKLQQIJ-UINYOVNOSA-N

Description

Biochem/physiol Actions

9(S)-HODE is a pro-inflammatory linoleic acid lipoxygenation product.

9(S)-HODE is produced by the lipoxygenation of linoleic acid. It is a major component of plasma oxidized low-density lipoprotein. 9-HODE has been shown to stimulate cell proliferation and and extracellular matrix synthesis in human mesangial cells via PPARgamma. Pro-inflammatory effects of 9-HODE, acting through the receptor GPR132, can contribute to atherosclerosis progression. 9-HODE has also been shown to activate spinal TRPV1, leading to inflammatory hyperalgesia.

Disclaimer

Supply conditions do not apply to the regions and states of Brazil: North, Northeast, Mato Grosso do Sul, Mato Grosso, and Rio Grande do Sul.

Safety Information

• pictograms: GHS02,GHS07
• signalword: Danger
• hcodes: H225,H319
• pcodes: P210 - P233 - P240 - P241 - P242 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Flam. Liq. 2
• Storage Class: 3 - Flammable liquids
• wgk: WGK 1
• flash_point_f: 57.2 °F - closed cup
• flash_point_c: 14.0 °C - closed cup