SML0496

CORM-3

Nitric oxide release inhibitor, powder

• Synonym(s): Carbon monoxide releasing molecule 3, Tricarbonylchloro(glycinato)ruthenium (II)
• Empirical Formula (Hill Notation): C₅H₄ClNO₅Ru
• CAS Number: 475473-26-8
• Molecular Weight: 294.61
• UNSPSC Code: 12352200
• NACRES: NA.77
• Form: powder
• Storage condition: desiccated

Properties

• Product Name: CORM-3,
• form: powder
• Quality Segment: 100
• storage condition: desiccated
• color: white to beige
• solubility: H₂O: 20 mg/mL, clear
• shipped in: wet ice
• storage temp.: −20°C
• SMILES string: [Ru+2].[Cl-].NCC(=O)[O-].O=[C].O=[C].O=[C]
• InChI: 1S/C2H5NO2.3CO.ClH.Ru/c3-1-2(4)5;3*1-2;;/h1,3H2,(H,4,5);;;;1H;/q;;;;;+2/p-2
• InChI key: BICHHHDSEZXKNN-UHFFFAOYSA-L

Description

Application

CORM-3 (carbon monoxide (CO) releasing molecule-3) has been used to study its effect on NLRP3 (leucine-rich-repeat-containing receptor, pyrin-domain-containing 3) inflammasome activation via glycolysis in macrophages and also on hyperglycemia-induced IL-1β (interleukin-1 β) production. It has also been used to study its protective function against H₂O₂-induced apoptosis using primary rabbit lens epithelial cells.

Biochem/physiol Actions

CORM-3 is a water-soluble carbon monoxide (CO) releasing molecule that can be used to study the effects of CO on cellular systems. Carbon monoxide (CO), produced during the degradation of heme by the enzyme heme oxygenase, has recently been found to be an important gaseous signaling mediator in mammalian cells CORM-3 has been shown to have anti-inflammatory and cardioprotective activity.

CORM-3 is a water-soluble carbon monoxide releasing molecule.

CO possesses anti apoptotic function and offers protection against oxidative damage, promoting endothelial healing. CORM-3 is known to have therapeutic effects in transplantation, myocardial infarction and rheumatoid arthritis.

Safety Information

• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable