SML0472
4-IPP
≥97% (HPLC)
Synonym(s):
4-Iodo-6-phenylpyrimidine
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
| Size/SKU | Availability | Price |
|---|---|---|
5 mg | Please contact Customer Service for Availability | 3 960,00 CZK |
25 mg | Please contact Customer Service for Availability | 15 900,00 CZK 13 515,00 CZK |
About This Item
Empirical Formula (Hill Notation):
C10H7IN2
CAS Number:
Molecular Weight:
282.08
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥97% (HPLC)
Form:
powder
Quality Segment
assay
≥97% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 10 mg/mL (clear solution, warmed)
storage temp.
−20°C
SMILES string
Ic1cc(ncn1)-c2ccccc2
InChI
1S/C10H7IN2/c11-10-6-9(12-7-13-10)8-4-2-1-3-5-8/h1-7H
InChI key
ZTCJXHNJVLUUMR-UHFFFAOYSA-N
Application
Biochem/physiol Actions
4-IPP is a cell permeable, potent macrophage migration inhibitory factor (MIF) antagonist that covalently modifies MIF N-terminal proline.
4-IPP is a cell permeable, potent macrophage migration inhibitory factor (MIF) antagonist.
4-Iodo-6-phenylpyrimidine (4-IPP) has the potential to be a new anti-polyploid therapeutic agent that may be utilized in patients with thyroid cancer to target polyploid tumor cells. It suppresses osteoclastogenesis by blocking the IMF-κB pathway. 4-IPP can be employed as a therapeutic target for macrophage migration inhibitory factor (MIF) to treat pathologic osteolytic bone diseases and postmenopausal bone loss. It can prevent the development and motility of lung adenocarcinoma cells and can stimulate apoptosis and mitotic death of thyroid carcinomas.
1 of 1
This Item | |||
|---|---|---|---|
| description ≥97% (HPLC) | description ≥98% (HPLC) | description ≥90% (HPLC) | description powder |
| form powder | form powder | form powder | form powder |
| assay ≥97% (HPLC) | assay ≥98% (HPLC) | assay ≥90% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. −20°C | storage temp. room temp | storage temp. 2-8°C | storage temp. room temp |
| solubility DMSO: 10 mg/mL (clear solution, warmed) | solubility DMSO: 10 mg/mL (clear solution) | solubility DMSO: >5 mg/mL | solubility DMSO: 5 mg/mL, clear |
| color white to beige | color white to beige | color white to beige | color yellow to orange-brown |
Storage Class
11 - Combustible Solids
wgk
WGK 3
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.