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SML0415

Alantolactone

≥98% (HPLC), activin/SMAD3 signaling inducer, powder

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Synonym(s):

(+)-Alantolactone., 3aR,5S,8aR,9aR)-3a,5,6,7,8,8a,9,9a-Octahydro-5,8a-dimethyl-3-methylene-naphtho[2,3-b]furan-2(3H)-one, Alant camphor, Elecampane camphor, Eupatal, Inula camphor, NSC 333843, NSC 93131

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Size/SKUAvailabilityPrice
5 mg
Please contact Customer Service for Availability
2 830,00 CZK
25 mg
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11 000,00 CZK

About This Item

Empirical Formula (Hill Notation):
C15H20O2
CAS Number:
546-43-0
Molecular Weight:
232.32
NACRES:
NA.77
PubChem Substance ID:
329825410
UNSPSC Code:
51111800
EC Number:
208-899-3
MDL number:
MFCD00274568
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated, protect from light

2 830,00 CZK

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Product Name

Alantolactone, ≥98% (HPLC)

Quality Segment

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated, protect from light

color

white to beige

solubility

DMSO: 15 mg/mL (clear solution)

storage temp.

−20°C

SMILES string

C[C@H]1CCC[C@]2(C)C[C@H]3OC(=O)C(=C)[C@H]3C=C12

InChI

1S/C15H20O2/c1-9-5-4-6-15(3)8-13-11(7-12(9)15)10(2)14(16)17-13/h7,9,11,13H,2,4-6,8H2,1,3H3/t9-,11+,13+,15+/m0/s1

InChI key

PXOYOCNNSUAQNS-AGNJHWRGSA-N

General description

Alantolactone is a compound produced by Inula helenium. Alantolactone has antibacterial, antifungal, anti-inflammatory and anticancer properties. It suppresses signal transducer and activator of transcription 3 (STAT3) activation in liver and breast cancer cells. Alantolactone induces apoptosis in A549 lung cancer cells.

Application

Alantolactone has been used:
  • in cell viability assay
  • to examine the percentage of multicentrosomal mitosis in low and high passage human embryonic stem cells (hESC)
  • in assessment of degranulation

Biochem/physiol Actions

Alantolactone is a sesquiterpene lactone disrupts the Cripto-1/ActRII complexes, resulting in an induction of activin/SMAD3 signaling. Alantolactone inhibits proliferation in cancer cells with no affect on normal cells.
Alantolactone is an inducer of activin/SMAD3 signaling.

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This Item
SML1766282146C0405000
Alantolactone ≥98% (HPLC)

Sigma-Aldrich

SML0415

Alantolactone

Diphyllin ≥98% (HPLC)

Sigma-Aldrich

SML1766

Diphyllin

(1R)-(−)-10-Camphorsulfonic acid 98%

Sigma-Aldrich

282146

(1R)-(−)-10-Camphorsulfonic acid

Camphor (racemic) European Pharmacopoeia (EP) Reference Standard

C0405000

Camphor (racemic)

description

≥98% (HPLC)

description

≥98% (HPLC)

description

98%

description

European Pharmacopoeia (EP) Reference Standard

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

98%

assay

-

form

powder

form

powder

form

-

form

-

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

-

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

-

storage temp.

-

storage condition

protect from light, desiccated

storage condition

-

storage condition

-

storage condition

-

solubility

DMSO: 15 mg/mL (clear solution)

solubility

DMSO: 5 mg/mL, clear (warmed)

solubility

-

solubility

-

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pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H317

Hazard Classifications

Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000567159
0000567158
0000033991
0000033993
0000020730

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