SML0391

SB-268262

≥98% (HPLC)

• Synonym(s): (+/-)-SB-273779, N-Methyl-N-(2-methylphenyl)-3-nitro-4-(2-thiazolylsulfinyl)-benzamide
• Empirical Formula (Hill Notation): C₁₈H₁₅N₃O₄S₂
• CAS Number: 217438-17-0
• Molecular Weight: 401.46
• NACRES: NA.77
• PubChem Substance ID: 329825388
• UNSPSC Code: 41106305
• MDL number: MFCD10565932
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: >5 mg/mL
• storage temp.: 2-8°C
• SMILES string: CN(C(=O)c1ccc(c(c1)[N+]([O-])=O)S(=O)c2nccs2)c3ccccc3C
• InChI: 1S/C18H15N3O4S2/c1-12-5-3-4-6-14(12)20(2)17(22)13-7-8-16(15(11-13)21(23)24)27(25)18-19-9-10-26-18/h3-11H,1-2H3
• InChI key: YXHLPJQQPOMPGE-UHFFFAOYSA-N

Description

Biochem/physiol Actions

SB-268262 is a selective non-peptide antagonist at the CGRP1 receptor.

SB-268262 is a selective non-peptide antagonist at the CGRP1 receptor. SB-268262 inhibits CGRP binding, and CGRP-mediated stimulation of adenylyl cyclase activity in human neuroblastoma cells with IC⁵⁰ values of 240 and 830 nM, respectively.

Features and Benefits

This compound is featured on the Calcitonin Gene-Related Peptides page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Codes: H302,H319
• Precautionary Statements: P264 - P270 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2
• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable