SML0343

Methylstat

≥98% (HPLC), Jumonji C domain-containing histone trimethyl demethylases (JHDMs) inhibitor, powder

• Synonym(s): (2E)-4-[Hydroxy[4-[[[4-[[[(1-naphthalenylamino)carbonyl]oxy]methyl]phenyl]methyl]amino]butyl]amino]-4-oxo-2-butenoic acid methyl ester
• Empirical Formula (Hill Notation): C₂₈H₃₁N₃O₆
• CAS Number: 1310877-95-2
• Molecular Weight: 505.56
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825348
• NACRES: NA.77
• MDL number: MFCD22572723
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Product Name: Methylstat, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: >5 mg/mL
• storage temp.: 2-8°C
• SMILES string: O=C(NC1=CC=CC2=C1C=CC=C2)OCC3=CC=C(CNCCCCN(O)C(/C=C/C(OC)=O)=O)C=C3
• InChI: 1S/C28H31N3O6/c1-36-27(33)16-15-26(32)31(35)18-5-4-17-29-19-21-11-13-22(14-12-21)20-37-28(34)30-25-10-6-8-23-7-2-3-9-24(23)25/h2-3,6-16,29,35H,4-5,17-20H2,1H3,(H,30,34)/b16-15+
• InChI key: MUJOCHRZXRZONW-FOCLMDBBSA-N

Description

Biochem/physiol Actions

Methylstat is an inhibitor of the Jumonji C domain-containing histone trimethyl demethylases (JHDMs).

Methylstat is an inhibitor of the Jumonji C domain-containing histone trimethyl demethylases (JHDMs). Methylstat inhibits the activity of JMJD2C (IC₅₀ = 4.3 μM), with similar potency against JMJD2E and JMJD3. The compound has poor activity against dimethyl demethylases, and does not inhibit class I or II HDACs. Methylsat blocks proliferation of the esophageal carcinoma cell line KYSE150 with an IC₅₀ value of 5.1 μM.

Safety Information

• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable