SML0330
S3I-201
≥97% (HPLC)
Synonym(s):
2-Hydroxy-4-[[[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino]-benzoic acid, NSC 74859
Select a Size
| Size/SKU | Availability | Price |
|---|---|---|
5 mg | Please contact Customer Service for Availability | 2 750,00 CZK 2 337,50 CZK |
25 mg | Please contact Customer Service for Availability | 11 600,00 CZK 9 860,00 CZK |
About This Item
2 337,50 CZK
List Price2 750,00 CZKSave 15%Quality Segment
assay
≥97% (HPLC)
form
powder
color
white to beige
solubility
DMSO: >10 mg/mL
storage temp.
−20°C
SMILES string
Cc1ccc(cc1)S(=O)(=O)OCC(=O)Nc2ccc(C(O)=O)c(O)c2
InChI
1S/C16H15NO7S/c1-10-2-5-12(6-3-10)25(22,23)24-9-15(19)17-11-4-7-13(16(20)21)14(18)8-11/h2-8,18H,9H2,1H3,(H,17,19)(H,20,21)
InChI key
HWNUSGNZBAISFM-UHFFFAOYSA-N
Application
- to confirm the role of STAT3 phosphorylation in interleukin (IL)-33 production in lung epithelial cells and IL-22 mRNA expression in sorted group 3 innate lymphoid cells (ILC3s)
- to study the cellular response of STAT3 triggered by β-hexaclorocyclohexane (β-HCH) in various cell lines
- to examine the influence of STAT3 in response to angiotensin II (ang II) on induction of fibrotic proteins in kidney epithelial cells
Biochem/physiol Actions
1 of 1
This Item | |||
|---|---|---|---|
| description ≥97% (HPLC) | description STAT3 Inhibitor VI, S3I-201, CAS 501919-59-1, is a cell-permeable compound that binds Stat3-SH2 domain and blocks Stat3 phosphorylation, dimerization, DNA-binding, & Stat3-dependent transcription. | description ≥98% (HPLC) | description ≥98% (HPLC) |
| assay ≥97% (HPLC) | assay ≥95% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| form powder | form solid | form powder | form powder |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. 2-8°C |
| solubility DMSO: >10 mg/mL | solubility DMSO: 10 mg/mL (Use only fresh, anhydrous DMSO.) | solubility DMSO: 20 mg/mL, clear | solubility DMSO: >10 mg/mL |
| color white to beige | color light beige | color white to beige | color white to beige |
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Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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