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SML0313

Pimelic Diphenylamide 106

≥98% (HPLC)

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Synonym(s):

Compound 106, Inhibitor 106, N1-(2-Aminophenyl)-N7-(4-methylphenyl)-heptanediamide, RGFA 8, TC-H 106

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Size/SKUAvailabilityPrice
5 mg
Please contact Customer Service for Availability
2 390,00 CZK
2 031,50 CZK
25 mg
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9 440,00 CZK

About This Item

Empirical Formula (Hill Notation):
C20H25N3O2
CAS Number:
Molecular Weight:
339.43
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder

2 031,50 CZK

List Price2 390,00 CZKSave 15%
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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: ≥15 mg/mL

storage temp.

2-8°C

SMILES string

Cc1ccc(NC(=O)CCCCCC(=O)Nc2ccccc2N)cc1

InChI

1S/C20H25N3O2/c1-15-11-13-16(14-12-15)22-19(24)9-3-2-4-10-20(25)23-18-8-6-5-7-17(18)21/h5-8,11-14H,2-4,9-10,21H2,1H3,(H,22,24)(H,23,25)

InChI key

WTKBRPXPNAKVEQ-UHFFFAOYSA-N

Biochem/physiol Actions

106 is a Class I HDAC inhibitor, demonstrating no activity against class II HDACs. It is a slow, tight-binding inhibitor of HDACs 1, 2, and 3, with a preference toward HDAC3 with Ki of 14 nM, 15 times lower than the Ki for HDAC1.
106 is a potent Class I HDAC inhibitor, demonstrating no activity against class II HDACs.
Pimelic diphenylamides has the ability to enhance the expression of the frataxin gene in lymphocytes from Friedreich ataxia patients.

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This Item
SML0813SML2937382173
description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

description

The Histone Deacetylase Inhibitor VII, 106, also referenced under CAS 937039-45-7, controls the biological activity of Histone Deacetylase. This small molecule/inhibitor is primarily used for Cell Structure applications.

form

powder

form

powder

form

powder

form

solid

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥95% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

solubility

DMSO: ≥15 mg/mL

solubility

DMSO: 2 mg/mL, clear (warmed)

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 10 mg/mL, ethanol: 2.5 mg/mL

color

white to beige

color

white to beige

color

white to beige

color

white


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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