SML0273

VAS2870

≥97% (HPLC), NOX4 inhibitor, powder

• Synonym(s): 1,3-Benzoxazol-2-yl-3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl sulfide, 7-(1,3-Benzoxazol-2-ylsulfanyl)-3-benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidine, 7-(2-Benzoxazolylthio)-3-(phenylmethyl)-3H-1,2,3-triazolo[4,5-d]pyrimidine, VAS 2870, VAS-2870
• Empirical Formula (Hill Notation): C₁₈H₁₂N₆OS
• CAS Number: 722456-31-7
• Molecular Weight: 360.39
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825281
• NACRES: NA.77
• MDL number: MFCD03407188
• Assay: ≥97% (HPLC)
• Form: powder

Properties

• Product Name: VAS2870, ≥97% (HPLC)
• Quality Segment: 100
• assay: ≥97% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: ≥5 mg/mL
• storage temp.: room temp
• SMILES string: C(c1ccccc1)n2nnc3c(Sc4nc5ccccc5o4)ncnc23
• InChI: 1S/C18H12N6OS/c1-2-6-12(7-3-1)10-24-16-15(22-23-24)17(20-11-19-16)26-18-21-13-8-4-5-9-14(13)25-18/h1-9,11H,10H2
• InChI key: HZSOKHVVANONPV-UHFFFAOYSA-N

Description

Application

VAS2870 has been used as a nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) inhibitor:

• to study the importance of NOX-derived reactive oxygen species in cytoskeletal organization, proper localization of E-cadherin and cell motility during zebrafish epiboly
• to study the function of Nox2 and Nox4 in lipopolysaccharide (LPS)-induced intestinal injury in high-fat diet (HFD) fed mice
• to reduce the reactive oxygen species level and study its influence on inhibiting the induction of trained innate immunity in monocytes

Biochem/physiol Actions

VAS2870 is a cell-permeable and specific NADPH oxidase (NOX) inhibitor that effectively suppresses growth factor-mediated ROS liberation in VSMC.

VAS2870 is a cell-permeable and specific NADPH oxidase (NOX) inhibitor.

In addition to NOX4 inhibition, VAS2870 is also known to supress the reactive oxygen species (ROS) production in several cell types. It effectively impairs cell growth and increases apoptosis induced by transforming growth factor β (TGF-β) in liver cancer cells. Thus, inhibition of NOX enzymes by VAS2870 may be considered as a potential therapeutic strategy for liver cancer.

Safety Information

• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable