SML0269

Nitisinone

≥95% (HPLC), 4-Hydroxyphenylpyruvate oxidase inhibitor, powder

• Synonym(s): 2-(2-Nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione, 2-[2-Nitro-4-(trifluoromethyl)benzoyl]cyclohexane-1,3-dione, NTBC, Nitisone, SC 0735
• Empirical Formula (Hill Notation): C₁₄H₁₀F₃NO₅
• CAS Number: 104206-65-7
• Molecular Weight: 329.23
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825277
• NACRES: NA.77
• MDL number: MFCD01752192
• Assay: ≥95% (HPLC)
• Form: powder

Properties

• Product Name: Nitisinone, ≥95% (HPLC)
• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: powder
• color: white to brown
• solubility: DMSO: ≥5 mg/mL
• storage temp.: −20°C
• SMILES string: [O-][N+](=O)c1cc(ccc1C(=O)C2C(=O)CCCC2=O)C(F)(F)F
• InChI: 1S/C14H10F3NO5/c15-14(16,17)7-4-5-8(9(6-7)18(22)23)13(21)12-10(19)2-1-3-11(12)20/h4-6,12H,1-3H2
• InChI key: OUBCNLGXQFSTLU-UHFFFAOYSA-N
• Gene Information: human ... HPD(3242)

Description

Application

Nitisinone has been used:

• to induce liver injury
• to treat Ixodes scapularis tick cells to inhibit the activity of hydroxyphenylpyruvate dioxygenase
• in supplemented water to block the accumulation of toxic metabolites in human hepatocyte engrafted mice
• to study its effect on bacterial pyomelanin production

Biochem/physiol Actions

Nitisinone is a competitive and reversible inhibitor of 4-Hydroxyphenylpyruvate oxidase (dioxygenase).

Nitisinone is a competitive inhibitor that reversibly inhibits 4-Hydroxyphenylpyruvate oxidase (dioxygenase). Nitisinone is used in the treatment of hereditary tyrosinemia type 1, where it blocks the degradation of tyrosine into harmful substances.

Safety Information

• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable