SML0230

GW-803430

≥98% (HPLC)

• Synonym(s): 6-(4-chloro-phenyl)-3-[3-methoxy-4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-3H-thieno[3,2-d]pyrimidin-4-one, GW-3430, GW-803430A
• Empirical Formula (Hill Notation): C₂₅H₂₄ClN₃O₃S
• CAS Number: 515141-51-2
• Molecular Weight: 481.99
• UNSPSC Code: 51111800
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: ≥4 mg/mL at warmed to 60 °C
• originator: GlaxoSmithKline
• storage temp.: 2-8°C
• SMILES string: [s]1c2c(nc[n]([c]2=O)c4cc(c(cc4)OCCN5CCCC5)OC)cc1c3ccc(cc3)Cl
• InChI: 1S/C25H24ClN3O3S/c1-31-22-14-19(8-9-21(22)32-13-12-28-10-2-3-11-28)29-16-27-20-15-23(33-24(20)25(29)30)17-4-6-18(26)7-5-17/h4-9,14-16H,2-3,10-13H2,1H3
• InChI key: MWULMTACIBZPGN-UHFFFAOYSA-N

Description

Application

GW-803430 may be used in MCHR1-mediated cell signaling studies.

Biochem/physiol Actions

GW-803430 antagonizes central MCHR1 and produces anxiolytic, anti-depressant and anti-obesity effects in rats and mice.[1] It also controls the alcohol-seeking behavior in rats and is a promising treatment for alcohol use-related disorders.[2]

GW-803430 is a centraly active and selective melanin-concentrating hormone receptor (MCHR) 1 antagonist

Features and Benefits

This compound is featured on the Melanin-Concentrating Hormone Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302,H319
• pcodes: P264 - P270 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable