SML0203

iCRT14

≥98% (HPLC), Wnt / β-catenin pathway inhibitor, powder

• Synonym(s): 5-[[2,5-Dimethyl-1-(3-pyridinyl)-1H-pyrrol-3-yl]methylene]-3-phenyl-2,4-thiazolidinedione
• Empirical Formula (Hill Notation): C₂₁H₁₇N₃O₂S
• CAS Number: 677331-12-3
• Molecular Weight: 375.44
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825227
• NACRES: NA.77
• MDL number: MFCD04366833
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Product Name: iCRT14, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: yellow to orange
• solubility: DMSO: ≥10 mg/mL
• storage temp.: 2-8°C
• SMILES string: Cc1cc(\C=C2/SC(=O)N(c3ccccc3)C2=O)c(C)n1-c4cccnc4
• InChI: 1S/C21H17N3O2S/c1-14-11-16(15(2)23(14)18-9-6-10-22-13-18)12-19-20(25)24(21(26)27-19)17-7-4-3-5-8-17/h3-13H,1-2H3/b19-12-
• InChI key: NCSHZXNGQYSKLR-UNOMPAQXSA-N

Description

Application

iCRT14 may be used in Wnt /β-catenin-mediated cell signaling studies.

Biochem/physiol Actions

Wnt / beta-catenin pathway inhibitor

iCRT14 is a Wnt / β-catenin pathway inhibitor. It is a potent inhibitor of Catenin Responsive Transcription (CRT) reporter genes, as well as endogenous gene targets. iCRT14 also disrupts β-catenin-TCF4 interaction in a dose dependent manner, and causes G₀/G₁ arrest in colon tumor lines.

iCRT14 belongs to the thiazolidinedione class of β-catenin-responsive transcription inhibitors. It decreases the levels of Dishevelled protein and modulates the binding of T-cell factor (TCF) to DNA. It results in consistent decrease in reduction of cell proliferation and tumor growth in colon cancer cells.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable