SML0180

Aceclidine hydrochloride

≥98% (HPLC)

• Synonym(s): 1-Azabicyclo[2.2.2]oct-3-yl acetate hydrochloride, 3-Acetoxyquinuclidine hydrochloride
• Empirical Formula (Hill Notation): C₉H₁₅NO₂ · HCl
• CAS Number: 6109-70-2
• Molecular Weight: 205.68
• PubChem Substance ID: 329825209
• UNSPSC Code: 12352200
• NACRES: NA.77
• EC Number: 228-071-5
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to tan
• solubility: H₂O: ≥15 mg/mL at ~60 °C
• storage temp.: −20°C
• SMILES string: Cl.CC(=O)O[C@H]1CN2CC[C@H]1CC2
• InChI: 1S/C9H15NO2.ClH/c1-7(11)12-9-6-10-4-2-8(9)3-5-10;/h8-9H,2-6H2,1H3;1H/t9-;/m0./s1
• InChI key: LWWSARSTZGNKGV-FVGYRXGTSA-N

Description

Application

Aceclidine hydrochloride may be used in muscarinic acetylcholine receptor-mediated cell signaling studies.

Biochem/physiol Actions

Aceclidine hydrochloride is a parasympathomimetic drug with weak anticholinesterase activity. It acts on cholinergic nerve-endings, lowers intraocular pressure and potent therapeutic agent for open-angle glaucoma.[1]

Aceclidine is a non-selective muscarinic acetylcholine receptor partial agonist that is effective in reducing intraocular pressure.

Muscarinic receptor partial agonist

Aceclidine at a concentration of 5 and 50 μg is capable of enhancing the outflow facility, following ciliary muscle disinsertion.

Features and Benefits

This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• pictograms: GHS06
• signalword: Danger
• hcodes: H301 + H311
• pcodes: P264 - P280 - P301 + P310 - P302 + P352 + P312 - P361 + P364 - P405
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Oral
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable