SML0176

Z36

≥98% (HPLC)

• Synonym(s): (Z)-5-Fluoro-1-(3′-dimethylamino)propyl-3-[(5′-methoxyindol-3-ylidene)methyl]-indolin-2-one, 1-[3-(dimethylamino)propyl]-5-fluoro-1,3-dihydro-3-[(5-methoxy-1H-indol-3-yl)methylene]-2H-Indol-2-one
• Empirical Formula (Hill Notation): C₂₃H₂₄FN₃O₂
• CAS Number: 1243148-19-7
• Molecular Weight: 393.45
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825205
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: light yellow to dark yellow
• solubility: DMSO: ≥15 mg/mL
• storage temp.: −20°C
• SMILES string: COc1ccc2[nH]cc(\C=C3/C(=O)N(CCCN(C)C)c4ccc(F)cc34)c2c1
• InChI: 1S/C23H24FN3O2/c1-26(2)9-4-10-27-22-8-5-16(24)12-19(22)20(23(27)28)11-15-14-25-21-7-6-17(29-3)13-18(15)21/h5-8,11-14,25H,4,9-10H2,1-3H3/b20-11-
• InChI key: CQNOITUXWKRVMB-JAIQZWGSSA-N

Description

Application

Z36 may be used to study cell signaling that results in autophagy.

Biochem/physiol Actions

Bcl-XL inhibitor that induces autophagic cell death independent of apoptosis

Z36 is a Bcl-XL inhibitor that induces autophagic cell death independent of apoptosis which distinguishes it from other Bcl-XL and Bcl-2 inhibitors that induce cancer cell death mainly through apoptosis. Z36 binds to the BH3 binding groove of BCL-XL where it is thought to induce autophagy through blocking the interaction between Bcl-XL/Bcl2 and Beclin 1.

Z36 inhibits cell proliferation and induces death in HeLa cells. The cell death induced is via autophagy and autophagic flux.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable