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SML0050

Sigma-Aldrich

CGP 37849

≥98% (HPLC)

Synonym(s):

(3E)-2-Amino-4-methyl-5-phosphono-3-pentanoic acid

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5 MG
CZK 2,040.00
25 MG
CZK 8,400.00

CZK 2,040.00

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5 MG
CZK 2,040.00
25 MG
CZK 8,400.00

About This Item

Empirical Formula (Hill Notation):
C6H12NO5P
CAS Number:
127910-31-0
Molecular Weight:
209.14
MDL number:
MFCD00153906
UNSPSC Code:
12352200
PubChem Substance ID:
329825119
NACRES:
NA.77

CZK 2,040.00

Please contact Customer Service for Availability
Request a Bulk Order

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: ≥2 mg/mL (warmed)

storage temp.

2-8°C

SMILES string

C\C(CP(O)(O)=O)=C/C(N)C(O)=O

InChI

1S/C6H12NO5P/c1-4(3-13(10,11)12)2-5(7)6(8)9/h2,5H,3,7H2,1H3,(H,8,9)(H2,10,11,12)/b4-2+

InChI key

BDYHNCZIGYIOGJ-DUXPYHPUSA-N

Application

CGP 37849 may be used in NMDA-mediated cell signaling studies.

Biochem/physiol Actions

CGP 37849 induces phencyclidine-like behavioral syndrome in amygdala-kindled rats that includes ataxia, locomotion and stereotypies.[1]
CGP 37849 is a potent orally active competitive NMDA antagonist and anticonvulsant.
Potent orally active competitive NMDA antagonist and anticonvulsant.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
032M4742V

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Krzysztof Wedzony et al.
Pharmacological reports : PR, 60(6), 856-864 (2009-02-13)
Postnatal hypofunction of N-methyl-D-aspartate (NMDA) receptors leads to several behavioral deficits in adult rats resembling deficits typical of schizophrenia-like deficits of sensorimotor gating. Thus far, it is not known whether the above disruptions are sensitive to neuroleptic drugs. In order
K Wedzony et al.
Neuroscience, 153(4), 1370-1379 (2008-04-25)
The malfunction of glutamatergic neurotransmission in the neonatal or postnatal periods may be a risk factor for the appearance of neuroanatomical, neurochemical or functional changes that are characteristic of schizophrenia. Thus, the present study was undertaken to investigate whether blockade
Małgorzata Dybała et al.
Journal of neural transmission (Vienna, Austria : 1996), 115(11), 1519-1520 (2008-10-08)
The NMDA receptor antagonist, CGP 37849-induced reduction in immobility time in the forced swim test in mice was not antagonized by pre-treatment with the AMPA receptor antagonist NBQX. This is the first demonstration of the antidepressant effect of the NMDA
Wojciech Zajaczkowski et al.
Polish journal of pharmacology, 55(5), 703-711 (2004-01-06)
In the present study, the interaction between a noncompetitive [(+)-MK-801] and a competitive (CGP 40116) NMDA receptor antagonists was tested in two different behavioral paradigms: locomotor activity test and prepulse inhibition of the acoustic startle reflex. Additionally, their effects on
Mélanie Langlois et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(49), 16523-16535 (2010-12-15)
Mesial temporal lobe epilepsy (MTLE) is characterized by focal seizures, associated with hippocampal sclerosis, and often resistance to antiepileptic drugs. The parafascicular nucleus (PF) of the thalamus is involved in the generation of physiological oscillatory rhythms. It receives excitatory inputs
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