SML0034

1-EBIO

≥98% (HPLC)

• Synonym(s): 1-Ethyl-1,3-dihydro-2H-benzimidazol-2-one; 1-Ethylbenzimidazolinone
• Empirical Formula (Hill Notation): C₉H₁₀N₂O
• CAS Number: 10045-45-1
• Molecular Weight: 162.19
• NACRES: NA.77
• PubChem Substance ID: 329825104
• UNSPSC Code: 12352200
• EC Number: 233-148-1
• MDL number: MFCD00005715
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• solubility: DMSO: ≥20 mg/mL
• storage temp.: room temp
• SMILES string: CCN1C(=O)Nc2ccccc12
• InChI: 1S/C9H10N2O/c1-2-11-8-6-4-3-5-7(8)10-9(11)12/h3-6H,2H2,1H3,(H,10,12)
• InChI key: CXUCKELNYMZTRT-UHFFFAOYSA-N

Description

Application

1-EBIO was used to study the electrical activity modulated by Ca⁺²-activated K⁺ channels in rat central neurons. The effect of 1-EBIO on human intermediate conductance channels was studied.

Biochem/physiol Actions

1-EBIO is an activator of epithelial Ca2+-activated K+ channel also known as the intermediate-conductance Ca(2+)-activated K(+) channel (IK-1) or KCa3.1.

1-EBIO is an activator of epithelial Ca²⁺-activated K⁺ channel

1-EBIO potentiates the secretion of CFTR-mediated Cl⁻ ion secretion by activating the basolateral KCNN4 K⁺ channels in native human colonic tissues. It stimulates the apical Cl⁻ channels and Ca⁺²-dependent basolateral K⁺ channels to stimulate fluid transport in lacrimal glands.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302,H319
• pcodes: P264 - P270 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable