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SCP0148
Furin Inhibitor II Peptide
≥95% (HPLC), lyophilized powder
Synonym(s):
Hexa-D-arginine amide
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| Size/SKU | Availability | Price |
|---|---|---|
5 mg | Please contact Customer Service for Availability | 7 510,00 CZK |
About This Item
Empirical Formula (Hill Notation):
C36H75N25O6
Molecular Weight:
954.14
UNSPSC Code:
12352202
NACRES:
NA.32
7 510,00 CZK
Please contact Customer Service for Availability
Product Name
Furin Inhibitor II,
assay
≥95% (HPLC)
form
lyophilized
composition
Peptide Content, ≥48%
storage condition
protect from light
technique(s)
protein extraction: suitable
input
mammalian sample(s)
storage temp.
−20°C
General description
Furin is a calcium-dependent serine endoproteinase and belongs to the subtilisin-like proprotein/prohormone convertase (PC) family. It is distributed ubiquitously and has a rhythmic movement between the trans-Golgi network, cell surface and the endosomes.
Application
Furin Inhibitor II has been used as a furin inhibitor:
- to study its effects on transforming growth factor β1 (TGF-β1) induced glial cell line-derived neurotrophic factor (GDNF) production in non-tumorigenic immortalized human granulosa cell line (SVOG).
- to study its effect on cleavage of (Pro) renin receptor (PRR) induced by bovine serum albumin (BSA) in human kidney 2 (HK-2) cells.
- in furin cleavage assay.
Biochem/physiol Actions
Furin plays a role in processing several pro-proteins such as, bone morphogenetic protein 4 (BMP-4), insulin receptor and Notch1 receptor. It also processes human immune deficiency virus 1 (HIV-1) glycoprotein gp160, several metalloproteases and pro-β-nerve growth (pro-β-NGF) factor. Furin is also involved in cleaving transforming growth factor β1 (TGF-β1).
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This Item | |||
|---|---|---|---|
| description - | description - | description Furin Inhibitor I, is a peptidyl chloromethylketone that binds to the catalytic site of furin and blocks its activity. | description targeting mouse Furin |
| assay ≥95% (HPLC) | assay ≥95% (HPLC) | assay ≥90% (HPLC) | assay - |
| technique(s) protein extraction: suitable | technique(s) - | technique(s) - | technique(s) - |
| form lyophilized | form lyophilized | form solid | form lyophilized powder |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| storage condition protect from light | storage condition protect from light | storage condition OK to freeze, desiccated | storage condition - |
| composition Peptide Content, ≥48% | composition Peptide Content, ≥80% | composition - | composition - |
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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How can Product SCP0148, Furin Inhibitor II be dissolved?
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Product SCP0148, Furin Inhibitor II, is soluble in water at a concentration of 1 mg/mL.
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How can product SCP0148, Furin Inhibitor II, be dissolved?
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Product SCP0148, Furin Inhibitor II is soluble in water at 1 mg/ml.
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