Anti-GLUR2 Antibody detects endogenous levels of total GLUR2 protein.
GLUR2 (glutamate receptor 2) is coded by gria2 gene. It is mapped to human chromosome 4q32. It is abundantly expressed in the brain.
Immunogen
The antiserum was produced against synthesized peptide derived from human GluR2.
Immunogen Range: 834-883
Application
Anti-GLUR2, C-Terminal antibody has been used in electron microscopy.
Biochem/physiol Actions
Presence of the glutamate receptor 2 (GluR2) subunit prevents calcium influx through AMPA-receptor complexes. Deletion of this subunit results in enhanced hippocampal long-term potentiation. As such, AMPA receptors play crucial roles in normal neuronal activity, including synaptic plasticity, synaptic scaling, homeostatic synaptic plasticity, learning and memory, as well as in synaptogenesis and the formation of neuronal circuitry.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 44(38) (2024-08-16)
Ribbon synapses of inner hair cells (IHCs) are uniquely designed for ultrafast and indefatigable neurotransmission of the sound. The molecular machinery ensuring the efficient, compensatory recycling of the synaptic vesicles (SVs), however, remains elusive. This study showed that hair cell
Specificity protein 4 (Sp4) regulates the transcription of AMPA receptor subunit GluA2 (Gria2)
Priya A, et al.
Biochimica et Biophysica Acta (2014)
Involvement of AMPA receptor GluR2 subunits in stimulus-reward learning: evidence from glutamate receptor gria2 knock-out mice
Mead AN and Stephens DN
The Journal of Neuroscience, 23 (2003)
Excitatory synaptic function and plasticity is persistently altered in ventral tegmental area dopamine neurons after prenatal ethanol exposure
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