S8627

Sulfacetamide

≥98.0%

• Synonym(s): N-(4-Aminobenzenesulfonyl)acetamide, N-(4-Aminophenylsulfonyl)acetamide, N¹-Acetylsulfanilamide
• Empirical Formula (Hill Notation): C₈H₁₀N₂O₃S
• CAS Number: 144-80-9
• Molecular Weight: 214.24
• UNSPSC Code: 51283901
• NACRES: NA.85
• PubChem Substance ID: 24899803
• EC Number: 205-640-6
• Beilstein/REAXYS Number: 981718
• MDL number: MFCD00066501

Properties

• assay: ≥98.0%
• antibiotic activity spectrum: Gram-negative bacteria, Gram-positive bacteria, mycoplasma
• mode of action: DNA synthesis | interferes
• SMILES string: CC(=O)NS(=O)(=O)c1ccc(N)cc1
• InChI: 1S/C8H10N2O3S/c1-6(11)10-14(12,13)8-4-2-7(9)3-5-8/h2-5H,9H2,1H3,(H,10,11)
• InChI key: SKIVFJLNDNKQPD-UHFFFAOYSA-N

Description

General description

Chemical structure: sulfonamide

Application

Sulfacetamide is used to study the treatment of acne and seborrheic dermatitis. It is used to study neonatal chlamydial conjunctivitis and meningococcal conjunctivitis.

Biochem/physiol Actions

Sulfacetamide is a sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfacetamide is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid. It is active against Gram positive bacteria, Gram negative bacteria and Chlamydia. Mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.

Packaging

100G,500G

Other Notes

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.Storage class (TRGS 510): Non Combustible Solids

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Codes: H317,H335
• Precautionary Statements: P261 - P271 - P272 - P280 - P302 + P352 - P304 + P340 + P312
• Hazard Classifications: Skin Sens. 1 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• WGK: WGK 2
• PPE (personal protective equipment): Eyeshields, Gloves, type N95 (US)