S8260

Salbutamol

≥96% (GC), powder, β2 adrenoceptor agonist

• Synonym(s): α-[(tert-Butylamino)methyl]-4-hydroxy-m-xylene-α,α′-diol, Albuterol
• Empirical Formula (Hill Notation): C₁₃H₂₁NO₃
• CAS Number: 18559-94-9
• Molecular Weight: 239.31
• NACRES: NA.77
• PubChem Substance ID: 24278712
• UNSPSC Code: 12352200
• EC Number: 242-424-0
• MDL number: MFCD00148978
• Beilstein/REAXYS Number: 6405698

Properties

• Product Name: Salbutamol,
• Quality Segment: 100
• solubility: methanol: complete 50 mg/ml, clear, colorless to yellow
• originator: GlaxoSmithKline
• SMILES string: CC(C)(C)NCC(O)c1ccc(O)c(CO)c1
• InChI: 1S/C13H21NO3/c1-13(2,3)14-7-12(17)9-4-5-11(16)10(6-9)8-15/h4-6,12,14-17H,7-8H2,1-3H3
• InChI key: NDAUXUAQIAJITI-UHFFFAOYSA-N
• Gene Information: human ... ADRB2(154)

Description

Application

Salbutamol was administered to primate model to study the bronchoconstriction in chronic allergic asthma.²⁰ Salbutamol was used as a standard for rapid pharmacokinetic screening of human plasma samples using HPLC.²¹

Biochem/physiol Actions

β₂-adrenoceptor agonist

Salbutamol is a β2 adrenoceptor agonist with short acting bronchodilation and anti-inflammatory effects. It relaxes the airway smooth muscles and inhibits bronchoconstriction induced by adenosine-5′ -monophosphate (AMP).¹ Salbutamol is particularly effective in treatment of asthma as it provides immediate relief.²

Features and Benefits

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Codes: H302,H317,H319,H412
• Precautionary Statements: P261 - P273 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Skin Sens. 1B
• Storage Class: 11 - Combustible Solids
• WGK: WGK 2
• PPE (personal protective equipment): dust mask type N95 (US), Eyeshields, Gloves