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Anti-Sodium Channel, Pan antibody produced in rabbit

Name: Anti-Sodium Channel, Pan antibody produced in rabbit
Brand: SIGMA
Price: 24000 CZK

affinity isolated antibody, lyophilized powder

Synonym(s):

Anti-SP19

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Size/SKU	Availability	Price
0.2 mL	Please contact Customer Service for Availability	CZK 24,000.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD02097413

Conjugate:

unconjugated

Clone:

polyclonal

Application:

IHC (p), IP, WB CL

Citations:

CZK 24,000.00

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Properties

biological source

rabbit

Quality Segment

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

rat

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable, immunoprecipitation (IP): suitable, western blot (chemiluminescent): 1:200-1:600

UniProt accession no.

P04774

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

rat ... Scn1a(81574)

Description

General description

Voltage-gated sodium channels (VGSC) are membrane proteins that are usually present in excitable cells. These sodium channels regulate neurological functions such as the generation of action potentials in nerve cells. Alterations in neurological sodium ion channels have been associated with epilepsy, whereas mutations in cardiac sodium channels have been linked to long QT syndrome . Anti-Sodium Channel, Pan antibody is specific for the α subunit of VGSC in rats.

Immunogen

synthetic peptide corresponding to amino acids 1491-1508 of the α subunit of rat type I voltage-gated sodium channel (VGSC, SP19) (with additional C-terminal cysteine). The epitope corresponds to the sequence in the intracellular loop between the III and IV domains of the VGSC α subunit.This epitope is identical in vertebrates, and highly homologous in mollusks and insects.

Application

Anti-Sodium Channel, Pan antibody is suitable for use in immunohistochemistry (formalin-fixed, paraffin-embedded sections), immunoprecipitation and chemiluminescent western blot.

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)
Immunohistochemistry (1 paper)

Physical form

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin, and 0.05% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	S2071	S0438	S8809
Sigma-Aldrich S6936 Anti-Sodium Channel, Pan antibody produced in rabbit	Sigma-Aldrich S2071 Anti-Sodium Channel Na_V1.8 antibody produced in rabbit	Sigma-Aldrich S0438 Anti-Sodium Channel PN4 antibody produced in rabbit	Sigma-Aldrich S8809 Monoclonal Anti-Sodium Channel, Pan antibody produced in mouse
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
Quality Level 100	Quality Level 200	Quality Level 200	Quality Level 200
antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form purified immunoglobulin
biological source rabbit	biological source rabbit	biological source rabbit	biological source mouse
technique(s) immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable, western blot (chemiluminescent): 1:200-1:600, immunoprecipitation (IP): suitable	technique(s) immunohistochemistry (frozen sections): suitable using adult rat DRG, western blot: 1:200 using rat DRG lysates	technique(s) western blot (chemiluminescent): 1:200	technique(s) immunohistochemistry (frozen sections): suitable, indirect immunofluorescence: 1 μg/mL using sciatic and optic nerve sections; cultured hypocampal neurons, western blot: 1 μg/mL using crude brain membrane prep (rat)
Gene Information rat ... Scn1a(81574)	Gene Information human ... SCN10A(6336) mouse ... Scn10a(20264) rat ... Scn10a(29571)	Gene Information human ... SCN8A(6334) mouse ... Scn8a(20273) rat ... Scn8a(29710)	Gene Information human ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN8A(6334), SCN9A(6335) mouse ... Scn10a(20264), Scn11a(24046), Scn1a(20265), Scn3a(20269), Scn4a(110880), Scn5a(20271), Scn8a(20273), Scn9a(20274) rat ... Scn10a(29571), Scn11a(29701), Scn1a(81574), Scn3a(497770), Scn4a(25722), Scn5a(25665), Scn8a(29710), Scn9a(78956)

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pictograms

GHS06

signalword

Danger

hcodes

H302 + H332,H311,H412

pcodes

P273 - P280 - P301 + P312 + P330 - P302 + P352 + P312 - P304 + P340 + P312

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c