S4503
DL-Serine hydroxamate
≥97% (TLC), suitable for ligand binding assays
Synonym(s):
SHX
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| Size/SKU | Availability | Price |
|---|---|---|
250 mg | Please contact Customer Service for Availability | CZK 12,400.00 |
1 g | Please contact Customer Service for Availability | CZK 40,800.00 |
About This Item
Empirical Formula (Hill Notation):
C3H8N2O3
CAS Number:
Molecular Weight:
120.11
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.26
MDL number:
Product Name
DL-Serine hydroxamate, seryl-tRNA synthetase inhibitor
Quality Segment
assay
≥97% (TLC)
form
powder
technique(s)
ligand binding assay: suitable
color
white to off-white
application(s)
cell analysis
storage temp.
−20°C
SMILES string
NC(CO)C(=O)NO
InChI
1S/C3H8N2O3/c4-2(1-6)3(7)5-8/h2,6,8H,1,4H2,(H,5,7)
InChI key
LELJBJGDDGUFRP-UHFFFAOYSA-N
Application
Serine has been used as an inhibitor of seryl-tRNA synthetase.[1][2] DL-Serine hydroxamate is used to induce metabolic synthesis of guanosine 3′-diphosphate 5′-diphosphate (ppGpp) in E. coli by amino acid starvation.[3] It is also used to synchronize cell cycle in E. coli cultures by inhibition of tRNA charging.[4]
Biochem/physiol Actions
Serine is involved in the one-carbon unit metabolism. It is associated with the biosynthesis of cysteine, ceramide, phosphatidylserine, purine and pyrimidine. In bacteria, it participates in tryptophan synthesis. Gluconeogenesis, one of the important biochemical processes, involves serine, particularly in ruminants. Protein phosphorylation is one such event that utilizes serine. Glycine, a metabolic product of serine, serves as an antioxidant and a neurotransmitter. D-serine is known to activate the N-methyl-D-aspartate (NMDA) receptors of the brain. Serine hydroxamate, a structural analogue of serine prevents seryl-tRNA (transfer ribonucleic acid) charging and thereby decreases phospholipid and nucleic acid synthesis in Escherichia coli.
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This Item | |||
|---|---|---|---|
| form powder | form powder | form powder | form powder |
| technique(s) ligand binding assay: suitable | technique(s) ligand binding assay: suitable | technique(s) ligand binding assay: suitable | technique(s) ligand binding assay: suitable |
| assay ≥97% (TLC) | assay ≥98.0% (TLC) | assay ≥98% (TLC) | assay >98% (TLC) |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| Quality Level 200 | Quality Level 100 | Quality Level 200 | Quality Level 200 |
| color white to off-white | color white to off-white | color white | color - |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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