S4447

α-Synuclein E46K human

recombinant, expressed in E. coli, N-terminal histidine tagged, ≥90% (SDS-PAGE), lyophilized powder

• Synonym(s): NACP (Non-a-beta component of Alzheimer disease amyloid, precursor), PARK1, PARK4, PD1, non A4 component of amyloid precursor
• NACRES: NA.32
• UNSPSC Code: 12352200

Properties

• recombinant: expressed in E. coli
• Quality Segment: 200
• assay: ≥90% (SDS-PAGE)
• form: lyophilized powder
• mol wt: apparent mol wt 19-20 kDa
• UniProt accession no.: P37840
• compatibility: for use with ABI StepOnePlus
• shipped in: dry ice
• storage temp.: −20°C
• Gene Information: human ... SNCA(6622)

Description

Biochem/physiol Actions

Among the familial mutations of α-synuclein in Parkinson′s disease, E46K has the greatest potential to aggregate. This mutation is a 188G-A tran­sition resulting in a Glu⁴⁶-to-Lys (E46K) substitution in the amino-terminal region of the protein.

Deposition of α-synuclein as fibrillary tangles is a hallmark of certain neurodegenerative diseases including Parkinson′s. Among the familial mutations of α-synuclein, E46K has the greatest potential to aggregate.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)