S3313

SB-204070 hydrochloride

solid, ≥97% (HPLC)

• Synonym(s): (1-Butyl-4-piperidinyl)methyl-8-amino-7-chloro-1,4-benzodioxane-5-carboxylate hydrochloride
• Empirical Formula (Hill Notation): C₁₉H₂₇ClN₂O₄ · HCl
• CAS Number: 148702-58-3
• Molecular Weight: 419.34
• NACRES: NA.77
• PubChem Substance ID: 24278704
• UNSPSC Code: 12352200
• MDL number: MFCD03453014
• Assay: ≥97% (HPLC)
• Form: solid

Properties

• Quality Segment: 100
• assay: ≥97% (HPLC)
• form: solid
• mp: 243-245 °C (lit.)
• solubility: H₂O: 20 mg/mL (with heating)
• SMILES string: Cl[H].CCCCN1CCC(CC1)COC(=O)c2cc(Cl)c(N)c3OCCOc23
• InChI: 1S/C19H27ClN2O4.ClH/c1-2-3-6-22-7-4-13(5-8-22)12-26-19(23)14-11-15(20)16(21)18-17(14)24-9-10-25-18;/h11,13H,2-10,12,21H2,1H3;1H
• InChI key: YEQGKAOSYSXEPU-UHFFFAOYSA-N
• Gene Information: human ... HTR4(3360)

Description

Application

SB-204070 hydrochloride was used to study the role of 5-HT metabolites in trypsin-induced anion secretion in mouse cecum.[1]

Biochem/physiol Actions

SB-204070 is a highly potent and specific antagonist of 4-HT₄ receptor. It inhibits cholinergic and noncholinergic transmission and blocks the contractions of proximal colon in guinea pigs[2][3] and relaxation of human colon circular smooth muscle.[4]

Selective 5-HT₄ serotonin receptor antagonist.

Legal Information

Manufactured and sold under exclusive license from GlaxoSmithKline Pharmaceuticals

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)