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S3136

[pGlu6]-Substance P Fragment 6-11

≥95% (HPLC)

Synonym(s):

pGlu-Phe-Phe-Gly-Leu-Met-NH2

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About This Item

Empirical Formula (Hill Notation):
C36H49N7O7S
CAS Number:
61123-13-5
Molecular Weight:
723.88
UNSPSC Code:
12352200
PubChem Substance ID:
24899545
MDL number:
MFCD00080132
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assay

≥95% (HPLC)

UniProt accession no.

P20366

storage temp.

−20°C

SMILES string

CSCCC(NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(Cc1ccccc1)NC(=O)C(Cc2ccccc2)NC(=O)C3CCC(=O)N3)C(N)=O

Gene Information

human ... TAC1(6863)

Biochem/physiol Actions

Substance P agonist; increased blood pressure when injected into cerebral ventricles of rat.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
087K1126
067K1921
037F01924
036H0318
121K1367

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O Gaffori et al.
Experientia, 40(1), 89-91 (1984-01-15)
N-terminal and C-terminal fragments of substance P (SP) have been shown to exert opposite effects on antinociception, grooming and fighting in mice. The present experiments explored whether these findings could be generalized to passive avoidance behavior. Substance P (SP-(1-11] and
Conformational studies on substance P. C-terminal pentapeptide pGlu-Phe-Phe-Gly-Leu-Met NH2.
M Cotrait et al.
Biochemical and biophysical research communications, 109(4), 1123-1128 (1982-12-31)
W A Turski et al.
The International journal of biochemistry, 17(10), 1097-1101 (1985-01-01)
Peptidase(s) activity of different subcellular fractions isolated from cortex, hippocampus, midbrain, thalamus with hypothalamus, cerebellum and medulla oblongata exerted against less than Glu SP6-11 (3H-Phen8) was evaluated in "low-ionic" and similar (in composition) to both extracellular and intracellular conditions. The
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