This product is lyophilized from a solution containing 11 mg sodium glutamate and 13 mg human albumin per 1 million units. The material is soluble in water, as well as in aqueous buffers compatible with the specific application. For testing purposes, the product is reconstituted in 10 mM Tris-HCl / 0.1 M NaCl / 0.1% BSA, pH 7.4. Working concentrations typically range from 5 - 20 units per mL and stock solutions may be prepared up to 1000 units per mL. Note that this enzyme is reversibly inactivated at or below pH 5 and irreversibly denatured at pH 9 or above. Prepared solutions are stable for several hours when refrigerated. For long term storage solutions may be stored at -20°C. Avoid repleated freeze/thaw cycles.
S3134
Streptokinase from β-hemolytic Streptococcus (Lancefield Group C)
lyophilized powder, ≥2,000 units/mg solid
Synonym(s):
Streptokinase from Streptococcus hemolyticus
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| Size/SKU | Availability | Price |
|---|---|---|
10000 units | Please contact Customer Service for Availability | 1 640,00 CZK |
50000 units | Please contact Customer Service for Availability | 5 220,00 CZK |
250000 units | Please contact Customer Service for Availability | 18 000,00 CZK |
About This Item
CAS Number:
eCl@ss:
32160410
UNSPSC Code:
12352204
NACRES:
NA.54
EC Number:
232-647-1
MDL number:
EC Number:
Specific activity:
≥2,000 units/mg solid
1 640,00 CZK
Please contact Customer Service for Availability
form
lyophilized powder
Quality Segment
specific activity
≥2,000 units/mg solid
shipped in
wet ice
storage temp.
−20°C
SMILES string
N1C(CC(C1)C2CCCCC2)C(=O)O
InChI
1S/C11H19NO2/c13-11(14)10-6-9(7-12-10)8-4-2-1-3-5-8/h8-10,12H,1-7H2,(H,13,14)
InChI key
XRZWVSXEDRYQGC-UHFFFAOYSA-N
General description
Research area: Cell signaling
Streptokinase is an extracellular enzyme produced by β-hemolytic Streptococcus. It is a single-chain polypeptide enzyme that consists of multiple structural domains, including α-, β-, and γ-domains.
Streptokinase is an extracellular enzyme produced by β-hemolytic Streptococcus. It is a single-chain polypeptide enzyme that consists of multiple structural domains, including α-, β-, and γ-domains.
Application
Streptokinase has been used in a study to compare primary coronary intervention and thrombolytic therapy in myocardial infarction patients.
Streptokinase is commonly used as a thrombolytic agent in the therapy of ischemic stroke. This therapy carries the important risk of intracerebral hemorrhage. Streptokinase is also used in the treatment of complicated parapneumonic effusions and empyema where adverse reactions, allergic type, are rare.
Biochem/physiol Actions
Streptokinase is a potent plasminogen activator. Unlike human proteins tissue plasminogen activator (tPA) and urokinase plasminogen activator (uPA), microbial streptokinase does not directly activate plasminogen. Instead, it activates plasminogen by fibrin-dependent and fibrin-independent. mechanisms. Streptokinase is effective in thrombolytic therapy. While streptokinase offers promising potential in treating ischemic stroke, its use also presents a significant risk of intracerebral hemorrhage. Streptokinase is also used in treating complicated parapneumonic effusions and empyema where allergic reactions, are rare.
Physical form
Lyophilized powder containing ~50% total protein by biuret and sodium glutamate. Total protein composed of enzyme protein and human serum albumin.
Other Notes
One unit is equal to the amount of activity in one unit from a Streptokinase International Standard reference vial.
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This Item | |||
|---|---|---|---|
| description lyophilized powder, ≥2,000 units/mg solid | description lyophilized solid, ≥3,500 unit/mg solid | description European Pharmacopoeia (EP) Reference Standard | description recombinant, expressed in E. coli |
| specific activity ≥2,000 units/mg solid | specific activity ≥3,500 unit/mg solid | specific activity - | specific activity - |
| form lyophilized powder | form lyophilized solid | form - | form lyophilized solid |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| shipped in wet ice | shipped in - | shipped in - | shipped in - |
| Quality Level 200 | Quality Level 200 | Quality Level - | Quality Level 100 |
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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volume required to reconstitute
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how to reconstitute
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This product is lyophilized from a solution containing sodium glutamate and human serum albumin. The material may be reconstituted in water. For assay purposes, this material is reconstituted in 10 mM Tris-HCl / 0.1 M NaCl / 0.1% BSA, pH 7.4 . The solution stability has not been determined.
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